Description

Methyl 2-[3-(4-Fluorophenyl)acryloyl]hydrazinecarboxylate is a specialized organic building block featuring a hydrazinecarboxylate core linked to a fluorinated cinnamoyl derivative. This compound matters for its role as a key synthetic intermediate in the development of novel pharmacologically active molecules, particularly in medicinal chemistry research. It is primarily needed by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in the synthesis of targeted therapeutics, agrochemicals, and advanced materials.

Application

• Pharmaceutical Intermediate: A crucial precursor in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders and inflammatory pathways.
• Agrochemical Research: Used in the development of next-generation herbicides and fungicides, leveraging the bioactivity of the fluorophenyl acryloyl moiety.
• Chemical Biology Probe Synthesis: Serves as a building block for creating molecular probes to study enzyme inhibition and protein-ligand interactions.
• Material Science: Potential intermediate for the synthesis of specialty polymers and advanced organic electronic materials.
• Academic & Contract Research: Employed in university and CRO settings for method development and exploratory synthetic chemistry projects.

Basic Information

Product Name	Methyl 2-[3-(4-Fluorophenyl)acryloyl]hydrazinecarboxylate
CAS No.	436155-62-3
Molecular Formula	C11H11FN2O3
Molecular Weight	238.22 g/mol
Synonyms	Methyl (2E)-2-[(3-(4-fluorophenyl)-1-oxo-2-propen-1-yl)hydrazino]formate; Methyl N'-(3-(4-fluorophenyl)acryloyl)hydrazinecarboxylate; (E)-Methyl 2-(3-(4-fluorophenyl)acryloyl)hydrazinecarboxylate; 4-Fluorocinnamoyl hydrazinecarboxylic acid methyl ester; Methyl carbazate, N'-(4-fluorocinnamoyl)-; 436155-62-3; Methyl 2-(3-(4-fluorophenyl)prop-2-enoyl)hydrazine-1-carboxylate
EINECS	Contact for details

Quality Control

Our Methyl 2-[3-(4-Fluorophenyl)acryloyl]hydrazinecarboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure consistency and compliance with research-grade specifications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from heat, sparks, and open flame. For long-term storage, consider inert atmosphere conditions to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.