Description

5-Thia-1-Azabicyclo[4.2.0]Oct-2-Ene-2-Carboxylic Acid, 7-Amino-8-Oxo-3-[(2S)-Tetrahydro-2-Furanyl]-, (6R,7R)- (9Ci, Aci) is a key advanced pharmaceutical intermediate with a complex bicyclic β-lactam structure. This compound is of significant commercial and research interest for its role in the synthesis of novel cephalosporin antibiotics. It is primarily required by pharmaceutical R&D laboratories and API manufacturers focused on developing next-generation antibacterial agents. Our supply ensures high purity and batch-to-batch consistency critical for sensitive synthetic pathways.

Application

• Pharmaceutical Intermediate: Serves as a critical building block in the synthesis of advanced cephalosporin-class antibiotics.
• Antibacterial Drug Research: Used in R&D for developing new β-lactam antibiotics with improved efficacy and resistance profiles.
• Active Pharmaceutical Ingredient (API) Synthesis: A key precursor in multi-step synthetic routes for final API production.
• Process Chemistry & Scale-Up: Employed in optimizing and scaling manufacturing processes from laboratory to pilot plant and commercial production.
• Chemical Reference Standard: Used as a high-purity standard for analytical method development, validation, and quality control in pharmaceutical analysis.
• Academic & Institutional Research: Utilized in universities and research institutes for studies on antibiotic synthesis, mechanism of action, and structure-activity relationships (SAR).

Basic Information

Item	Details
Product Name	5-Thia-1-Azabicyclo[4.2.0]Oct-2-Ene-2-Carboxylic Acid, 7-Amino-8-Oxo-3-[(2S)-Tetrahydro-2-Furanyl]-, (6R,7R)- (9Ci, Aci)
CAS No.	436100-71-9
Molecular Formula	C11H14N2O4S
Molecular Weight	270.30 g/mol
Synonyms	(6R,7R)-7-Amino-8-oxo-3-[(2S)-tetrahydrofuran-2-yl]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid; 7-Amino-3-[(2S)-tetrahydro-2-furanyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic Acid, (6R,7R)-; Cephalosporin nucleus derivative; 3-(Tetrahydrofuran-2-yl)-7-ACA derivative; β-lactam intermediate; CAS 436100-71-9
EINECS	Contact for details

Quality Control

Our 5-Thia-1-Azabicyclo[4.2.0]Oct-2-Ene-2-Carboxylic Acid, 7-Amino-8-Oxo-3-[(2S)-Tetrahydro-2-Furanyl]-, (6R,7R)- (9Ci, Aci) is manufactured under strict quality management systems to ensure it meets the exacting standards required for pharmaceutical synthesis. Each batch undergoes comprehensive analytical testing, including HPLC for purity and chiral purity verification. Certificates of Analysis (COA) documenting identity, purity, and impurity profiles are provided and available upon request to support your regulatory and quality assurance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed and under an inert atmosphere (e.g., nitrogen) for long-term storage to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% (6R,7R,2S)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.