Description

1-Bromo-3-(Difluoromethoxy)-5-Fluorobenzene is a high-value, multi-halogenated aromatic building block of significant interest in advanced organic synthesis. Its unique structure, featuring bromine, fluorine, and a difluoromethoxy group, makes it a critical intermediate for constructing complex molecules with tailored electronic and steric properties. This compound is primarily utilized by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for the development of new active ingredients, where its halogen substituents are leveraged for bioisosteric replacement and metabolic stability enhancement.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of novel active pharmaceutical ingredients (APIs), particularly in medicinal chemistry programs targeting CNS disorders, oncology, and anti-infectives.
• Agrochemical Synthesis: Serves as a versatile building block for creating advanced herbicides, fungicides, and insecticides, where the fluorine and bromine atoms contribute to efficacy and environmental persistence profiles.
• Liquid Crystal & OLED Materials: Used in the synthesis of fluorinated aromatic cores for electronic materials, contributing to the desired dielectric anisotropy and stability in display technologies.
• Cross-Coupling Reactions: The bromine atom is an excellent handle for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck, Sonogashira), enabling rapid diversification of the benzene core.
• Fluorine Chemistry Research: An important substrate for studying the influence of the difluoromethoxy group (-OCF2H) on reactivity and physicochemical properties in comparison to methoxy or trifluoromethoxy analogs.
• Polymer Modification: Can be incorporated as a monomer or modifier to introduce halogenated aromatic units into specialty polymers, affecting their thermal and chemical resistance.

Basic Information

Product Name	1-Bromo-3-(Difluoromethoxy)-5-Fluorobenzene
CAS No.	433939-28-7
Molecular Formula	C7H4BrF3O
Molecular Weight	241.01 g/mol
Synonyms	3-Bromo-5-fluorophenyl difluoromethyl ether; 5-Fluoro-3-bromophenyl difluoromethyl ether; Benzene, 1-bromo-3-(difluoromethoxy)-5-fluoro-; 1-Bromo-3-(difluoromethoxy)-5-fluorobenzene; 5-Fluoro-1-bromo-3-(difluoromethoxy)benzene; 3-(Difluoromethoxy)-5-fluorobromobenzene
EINECS	Contact for details

Quality Control

Our production of 1-Bromo-3-(Difluoromethoxy)-5-Fluorobenzene adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity for sensitive synthetic applications. Each lot is characterized using advanced analytical techniques including GC, HPLC, NMR, and MS to confirm identity and quantify impurities. Certificates of Analysis (COA) detailing all relevant specifications are provided with every shipment. We support cGMP-compliant manufacturing for pharmaceutical customers and can tailor purity grades to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong acids and incompatible organic solvents. For long-term storage, consider using amber glass containers or opaque packaging to minimize light exposure.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0% (Area %)
Water Content (KF)	≤ 0.5%
Related Substances (GC/HPLC)	Individual impurity ≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.