Description

3-Chloro-5-(Trifluoromethoxy)Phenylacetic Acid is a high-purity fluorinated aromatic building block of significant importance in advanced organic synthesis. This compound is valued for its unique molecular structure, which combines a phenylacetic acid core with chloro and trifluoromethoxy substituents, enabling precise modulation of physicochemical properties in target molecules. It is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients, where its fluorine-containing moiety is critical for enhancing metabolic stability, bioavailability, and binding affinity.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new drug candidates, particularly for central nervous system (CNS) agents, anti-inflammatory drugs, and other bioactive molecules.
• Agrochemical Synthesis: Used in the creation of advanced herbicides, fungicides, and insecticides, where the trifluoromethoxy group contributes to improved lipophilicity and environmental stability.
• Liquid Crystal & OLED Materials: Serves as a precursor in the synthesis of fluorinated organic electronic materials for displays and lighting applications.
• Advanced Polymer Modifiers: Incorporated as a monomer or additive to impart specific chemical resistance, thermal stability, or surface properties to high-performance polymers.
• Chemical Research & Development: Employed in academic and industrial labs for method development, catalysis studies, and exploring novel reaction pathways involving fluorinated aromatics.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of bespoke compounds and complex molecules under cGMP conditions.

Basic Information

Product Name	3-Chloro-5-(Trifluoromethoxy)Phenylacetic Acid
CAS No.	433938-70-6
Molecular Formula	C9H6ClF3O3
Molecular Weight	254.59 g/mol
Synonyms	[3-Chloro-5-(trifluoromethoxy)phenyl]acetic acid; 2-[3-Chloro-5-(trifluoromethoxy)phenyl]acetic acid; 3-Chloro-5-(trifluoromethoxy)benzeneacetic acid; (3-Chloro-5-trifluoromethoxyphenyl)acetic acid; 433938-70-6; 3-Chloro-5-(trifluoromethoxy)benzenacetic acid; α-(3-Chloro-5-(trifluoromethoxy)phenyl)acetic acid
EINECS	Contact for details

Quality Control

Our 3-Chloro-5-(Trifluoromethoxy)Phenylacetic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment supports applications requiring high-purity intermediates, including those under research for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). Keep away from strong bases, strong oxidizing agents, and sources of ignition. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.