Description

Fmoc-2-Fluoro-Dl-Phenylglycine is a non-natural, fluorinated amino acid derivative protected with a 9-fluorenylmethoxycarbonyl (Fmoc) group. This compound is a critical building block in modern solid-phase peptide synthesis (SPPS), where the fluorine atom on the aromatic ring can be leveraged to modulate the peptide's biological activity, stability, and binding affinity. It is primarily utilized by pharmaceutical R&D departments, biotechnology companies, and academic research institutions focused on developing novel peptide-based therapeutics, diagnostic agents, and biochemical probes.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected amino acid for the automated, stepwise synthesis of complex peptides and small proteins.
• Pharmaceutical Research: Incorporation into peptide drug candidates to enhance metabolic stability, improve receptor selectivity, or introduce positron emission tomography (PET) imaging capabilities via the fluorine-18 isotope.
• Chemical Biology & Proteomics: Used to create fluorinated peptide analogs for studying protein-protein interactions, enzyme mechanisms, and structure-activity relationships (SAR).
• Material Science: Synthesis of fluorinated peptide-polymer conjugates or bio-inspired materials with unique surface properties.
• Agrochemical Development: Building block for novel fluorinated peptide-based pesticides or growth regulators.

Basic Information

Product Name	Fmoc-2-Fluoro-Dl-Phenylglycine
CAS No.	433291-96-4
Molecular Formula	C22H18FNO4
Molecular Weight	379.38 g/mol
Synonyms	N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-2-fluoro-2-phenylglycine; Fmoc-2-Fluoro-DL-α-phenylglycine; N-Fmoc-2-fluoro-2-phenylglycine; (±)-N-(9-Fluorenylmethoxycarbonyl)-2-fluoro-2-phenylglycine; 2-Fluoro-N-Fmoc-phenylglycine; Fmoc-2-F-Pheg-OH; 9-Fluorenylmethyl N-(2-fluoro-2-phenylglycyl)carbamate
EINECS	Contact for details

Quality Control

Our Fmoc-2-Fluoro-Dl-Phenylglycine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and chiral analysis to verify the racemic mixture. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with your research or cGMP starting material requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as specified on the label. This material is hygroscopic (moisture-sensitive); keep the container tightly sealed in a desiccated environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residue on Ignition	≤ 0.5%
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.