Description

3-Butyn-2-One, 1-Bromo-4-(Trimethylsilyl)- is a high-value, specialized organosilicon building block containing both a bromine substituent and a terminal alkyne functionality. This unique bifunctional structure makes it a critical intermediate for advanced organic synthesis, particularly in the construction of complex molecular architectures. It is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and materials science sectors who require precise and reliable synthetic precursors for drug discovery and specialty polymer development.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of active pharmaceutical ingredients (APIs), especially for compounds requiring alkyne or silicon-containing moieties.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and plant growth regulators.
• Material Science & Polymer Chemistry: Acts as a monomer or cross-linking agent for creating specialty polymers, silicones, and advanced materials with tailored properties.
• Organic Synthesis Building Block: Utilized in Sonogashira coupling, click chemistry, and other palladium-catalyzed cross-coupling reactions to introduce acetylene and trimethylsilyl groups.
• Ligand & Catalyst Development: Employed in the preparation of novel ligands and organometallic catalysts for asymmetric synthesis.
• Life Sciences & Bioconjugation: Functions as a reagent for labeling biomolecules (proteins, nucleic acids) via its reactive alkyne handle.

Basic Information

Product Name	3-Butyn-2-One, 1-Bromo-4-(Trimethylsilyl)-
CAS No.	433257-41-1
Molecular Formula	C7H11BrOSi
Molecular Weight	219.15 g/mol
Synonyms	1-Bromo-4-(trimethylsilyl)-3-butyn-2-one; 4-Bromo-1-(trimethylsilyl)-2-propyn-1-one; 1-Bromo-4-(trimethylsilyl)but-3-yn-2-one; 3-Butyn-2-one, 1-bromo-4-(trimethylsilyl)-; Bromo(trimethylsilyl)acetylacetone derivative; TMS-protected bromoacetylene ketone
EINECS	Contact for details

Quality Control

Our production of 3-Butyn-2-One, 1-Bromo-4-(Trimethylsilyl)- adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity. Each lot is analyzed using advanced techniques including GC, HPLC, and NMR spectroscopy. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong acids and incompatible organic solvents. Due to its light-sensitive nature, containers should be kept in opaque or amber glass, or stored in dark conditions.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.