Description

D-Proline, 5-(1-Methylethyl)-, (5R)-Rel- (9Ci) is a non-proteinogenic, chiral proline derivative featuring an isopropyl substituent at the 5-position of the pyrrolidine ring. This compound is a valuable, high-purity chiral building block and intermediate for the synthesis of complex pharmaceuticals and bioactive molecules. It is primarily utilized by research institutions and pharmaceutical companies engaged in asymmetric synthesis, peptide mimetic development, and the creation of novel active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A key chiral synthon in the asymmetric synthesis of drug candidates, particularly for protease inhibitors and other targeted therapies.
• Peptidomimetics & Constrained Peptides: Used to introduce conformational constraints and enhance metabolic stability in peptide-based drug design.
• Asymmetric Catalysis: Serves as a precursor for chiral ligands and organocatalysts used in enantioselective transformations.
• Chemical Biology & Proteomics: Employed as a tool compound or a modified amino acid in biochemical studies and probe development.
• Agrochemical Research: Potential intermediate for the synthesis of chiral, bioactive compounds in crop protection.
• Academic & Process R&D: Used in methodological development and scale-up studies for novel synthetic routes.

Basic Information

Product Name	D-Proline, 5-(1-Methylethyl)-, (5R)-Rel- (9Ci)
CAS No.	428820-25-1
Molecular Formula	C8H15NO2
Molecular Weight	157.21 g/mol
Synonyms	(5R)-5-Isopropyl-D-proline; (R)-5-Isopropyl-D-proline; D-5-Isopropylproline; rel-(5R)-5-(1-Methylethyl)-D-proline; (R)-5-(Propan-2-yl)pyrrolidine-2-carboxylic acid; 428820-25-1; (5R)-5-(Propan-2-yl)-D-proline
EINECS	Contact for details

Quality Control

Our D-Proline, 5-(1-Methylethyl)-, (5R)-Rel- (9Ci) is produced under a strict quality management system. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for pharmaceutical R&D and synthesis. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.