Description

2-[4-(Trifluoromethoxy)Phenyl]Acetohydrazide is a high-purity organic intermediate featuring a trifluoromethoxy phenyl group, a structure that imparts unique physicochemical properties critical for advanced synthesis. This compound matters for its role as a versatile building block in the development of active pharmaceutical ingredients (APIs) and agrochemicals, where the introduction of fluorine-containing groups is often essential for enhancing metabolic stability and bioactivity. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries seeking to innovate new molecules with improved performance profiles.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, particularly in central nervous system (CNS) and anti-inflammatory therapeutic areas.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where the trifluoromethoxy group can improve lipophilicity and biological activity.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands used in catalytic processes and metal-organic frameworks (MOFs).
• Material Science Research: Employed in the development of organic electronic materials and advanced polymers with specific thermal and chemical resistance properties.
• Custom Synthesis and Contract Manufacturing: A critical starting material for custom synthesis projects and scale-up services for clients requiring fluorinated aromatic compounds.

Basic Information

Item	Details
Product Name	2-[4-(Trifluoromethoxy)Phenyl]Acetohydrazide
CAS No.	428508-17-2
Molecular Formula	C9H9F3N2O2
Molecular Weight	234.18 g/mol
Synonyms	2-[4-(Trifluoromethoxy)phenyl]acetohydrazide; 4-(Trifluoromethoxy)phenylacetic acid hydrazide; 2-(4-(Trifluoromethoxy)phenyl)acetohydrazide; α-(4-Trifluoromethoxyphenyl)acetohydrazide; (4-Trifluoromethoxyphenyl)acetic acid hydrazide; Acetohydrazide, 2-[4-(trifluoromethoxy)phenyl]-; TFMPAH
EINECS	Contact for details

Quality Control

Our 2-[4-(Trifluoromethoxy)Phenyl]Acetohydrazide is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your most demanding synthesis applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its sensitivity to oxidation, it is recommended to store the material under an inert atmosphere (e.g., nitrogen or argon) for long-term preservation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.