Description

Boc-4,4-Difluoro-L-Prolinamide is a high-purity, fluorinated proline derivative used as a critical building block in advanced organic synthesis. This compound is specifically engineered to introduce conformational rigidity and enhance metabolic stability in peptide-based pharmaceuticals and bioactive molecules. It is an essential intermediate for researchers and manufacturers in the pharmaceutical, biotechnology, and agrochemical industries developing novel therapeutics and chemical probes.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of fluorinated peptide drugs and protease inhibitors.
• Peptidomimetics Development: Used to incorporate constrained, fluorinated proline analogs into peptidomimetic scaffolds to improve bioavailability and binding affinity.
• Chemical Biology Probes: Serves as a building block for creating fluorinated probes used in studying enzyme mechanisms and protein-protein interactions.
• Agrochemical Research: Employed in the research and development of novel, fluorinated active ingredients with enhanced properties.
• Material Science: Potential monomer for specialty polymers where fluorine incorporation can alter surface properties and stability.

Basic Information

Product Name	Boc-4,4-Difluoro-L-Prolinamide
CAS No.	426844-50-0
Molecular Formula	C₁₀H₁₆F₂N₂O₃
Molecular Weight	250.24 g/mol
Synonyms	(2S)-1-[(2-Methylpropan-2-yl)oxycarbonyl]-4,4-difluoropyrrolidine-2-carboxamide; N-(tert-Butoxycarbonyl)-4,4-difluoro-L-prolinamide; Boc-4,4-Difluoro-L-proline amide; tert-Butyl (2S)-4,4-difluoro-2-(aminocarbonyl)pyrrolidine-1-carboxylate; (S)-1-(tert-Butoxycarbonyl)-4,4-difluoropyrrolidine-2-carboxamide; 4,4-Difluoro-L-prolinamide, N-Boc-protected; N-Boc-4,4-difluoro-L-prolinamide
EINECS	Contact for details

Quality Control

Our Boc-4,4-Difluoro-L-Prolinamide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and chiral integrity suitable for research and cGMP applications. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label or CoA. This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.