Description

Erythromycin (n-Methyl-13C, 99%) is a stable isotope-labeled analog of the macrolide antibiotic erythromycin, where the n-methyl group is enriched with carbon-13 to 99% isotopic purity. This high-purity labeled compound is an essential internal standard and tracer for advanced quantitative mass spectrometry and metabolic flux analysis in pharmaceutical research. It is primarily used by researchers and analytical laboratories in drug metabolism and pharmacokinetics (DMPK) studies, proteomics, and the development of precise bioanalytical methods.

Application

• Internal Standard for LC-MS/MS: Serves as a critical, non-interfering internal standard for the accurate quantification of erythromycin and its metabolites in complex biological matrices like plasma, serum, and tissue homogenates.
• Metabolic Pathway Tracing: Used in in vitro and in vivo studies to elucidate the detailed metabolic fate and biotransformation pathways of erythromycin using isotope-ratio mass spectrometry.
• Pharmaceutical R&D: Supports drug discovery and development by enabling precise pharmacokinetic profiling, bioavailability studies, and stability testing under Good Laboratory Practice (GLP) standards.
• Proteomics & Biomarker Research: Facilitates stable isotope labeling strategies in proteomic workflows for relative and absolute protein quantification.
• Quality Control & Method Validation: Employed in analytical method development and validation within quality control laboratories to ensure accuracy, precision, and regulatory compliance (e.g., FDA, EMA).
• Environmental & Food Safety Analysis: Acts as a reference standard in the detection and quantification of erythromycin residues in environmental water samples and food products.

Basic Information

Product Name	Erythromycin (n-Methyl-13C, 99%)
CAS No.	425623-74-1
Molecular Formula	C37H6613CNO13
Molecular Weight	~ 736.00 g/mol (for 13C labeled form)
Synonyms	Erythromycin n-Methyl-13C; Erythromycin (Methyl-13C); [13C]Methyl Erythromycin; Erythromycin A (n-Methyl-13C); (3R,4S,5S,6R,7R,9R,11R,12R,13S,14R)-4-[(2,6-Dideoxy-3-C-methyl-3-O-methyl-α-L-ribo-hexopyranosyl)oxy]-14-ethyl-7,12,13-trihydroxy-3,5,7,9,11,13-hexamethyl-6-[[3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosyl]oxy]oxacyclotetradecane-2,10-dione (n-Methyl-13C); Abbott 29007; EM; ERY; Ilotycin
EINECS	Contact for details

Quality Control

Every batch of Erythromycin (n-Methyl-13C, 99%) is manufactured and analyzed under strict quality systems. Our products undergo rigorous identity, purity, and isotopic enrichment testing to ensure compliance with research-grade standards. A comprehensive Certificate of Analysis (COA) is provided with each shipment, detailing results for isotopic purity, chemical purity (HPLC), and identification.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C. The product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Isotopic Purity (13C)	≥ 99%
Chemical Purity (HPLC)	≥ 98%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.