Description

(1R,2R)-1,2-Bis(2,4,6-Trimethylphenyl)Ethylenediamine is a high-value, chiral diamine ligand characterized by its sterically demanding mesityl substituents. This compound matters for its exceptional ability to induce stereoselectivity in asymmetric catalysis, a critical process for synthesizing enantiomerically pure pharmaceuticals and fine chemicals. It is primarily needed by R&D chemists and process development teams in the pharmaceutical, agrochemical, and specialty chemical industries who require reliable, high-purity chiral auxiliaries to develop efficient synthetic routes.

Application

• Asymmetric Catalysis: As a privileged chiral ligand in transition metal-catalyzed reactions, including hydrogenation, hydrosilylation, and C-C bond-forming reactions.
• Pharmaceutical Intermediates: For the enantioselective synthesis of active pharmaceutical ingredients (APIs) where precise chirality is essential for biological activity.
• Agrochemical Synthesis: In the production of chiral herbicides, fungicides, and pesticides to enhance efficacy and reduce environmental impact.
• Academic & Industrial Research: As a key reagent for developing new catalytic methodologies and exploring novel asymmetric transformations.
• Fine Chemical Production: For manufacturing enantiomerically pure flavors, fragrances, and advanced materials.
• Ligand for Metal Complexes: Used to prepare well-defined chiral metal complexes for mechanistic studies and catalyst screening.

Basic Information

Product Name	(1R,2R)-1,2-Bis(2,4,6-Trimethylphenyl)Ethylenediamine
CAS No.	425615-42-5
Molecular Formula	C22H30N2
Molecular Weight	322.49 g/mol
Synonyms	(1R,2R)-(-)-1,2-Bis(2,4,6-trimethylphenyl)ethylenediamine; (R,R)-TMEDA; (R,R)-Bis(mesityl)ethylenediamine; (1R,2R)-1,2-Di(2,4,6-trimethylphenyl)ethane-1,2-diamine; (R,R)-Diaminomesitylene Ethylene; Jacobsen's Ligand (variant); Chiral Diamine Ligand; (R,R)-Bis(2,4,6-trimethylphenyl)ethylenediamine
EINECS	Contact for details

Quality Control

Our (1R,2R)-1,2-Bis(2,4,6-Trimethylphenyl)Ethylenediamine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC and NMR, to ensure high enantiomeric excess (ee) and chemical purity suitable for sensitive catalytic applications. Certificates of Analysis (COA) with detailed chromatographic data are available upon request to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This material is light-sensitive (store away from light). Keep container tightly sealed to minimize exposure to air and moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0% ee
Melting Point	Contact for details
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.