Description

Methyl 3-Chloro-2-Cyano-4,4-Difluorocrotonate CAS NO 425395-33-1 is a high-value fluorinated building block and versatile synthon in advanced organic synthesis. Its molecular structure, featuring reactive chloro, cyano, and difluoroalkene functionalities, makes it a critical intermediate for constructing complex heterocycles and fluorinated target molecules. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for developing novel active ingredients with enhanced properties.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of fluorinated pyrimidines, pyridines, and other nitrogen-containing heterocycles with potential biological activity.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides where the introduction of fluorine atoms improves efficacy and environmental profile.
• Material Science Precursor: Serves as a monomer or cross-linking agent in the development of specialty polymers and advanced materials with unique surface properties.
• Fluorine Chemistry Research: A valuable reagent for studying cycloaddition reactions, nucleophilic substitutions, and other transformations involving gem-difluoroalkenes.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs for the production of proprietary compounds and development candidates at various scales.

Basic Information

Product Name	Methyl 3-Chloro-2-Cyano-4,4-Difluorocrotonate
CAS No.	425395-33-1
Molecular Formula	C6H4ClF2NO2
Molecular Weight	195.55 g/mol
Synonyms	Methyl 3-chloro-2-cyano-4,4-difluorobut-2-enoate; 2-Butenoic acid, 3-chloro-2-cyano-4,4-difluoro-, methyl ester; 3-Chloro-2-cyano-4,4-difluorocrotonic acid methyl ester; Methyl 3-chloro-2-cyano-4,4-difluoro-2-butenoate; (Z/E)-Methyl 3-chloro-2-cyano-4,4-difluorocrotonate; 425395-33-1; Fluorinated crotonate ester intermediate
EINECS	Contact for details

Quality Control

Every batch of Methyl 3-Chloro-2-Cyano-4,4-Difluorocrotonate is produced and tested under a strict quality management system. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) are available upon request, detailing purity, identity, and impurity profiles to support your R&D and production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong bases and incompatible organic solvents. The container should be kept tightly sealed to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Purity (GC)	≥ 96.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Isomer Ratio (Z/E)	Specified on COA

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.