Description

Samidorphan is a selective opioid receptor antagonist with high affinity for the mu-opioid receptor. This compound is of significant interest in pharmaceutical research and development, particularly for its potential in modulating opioid system activity. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel therapeutics for addiction, pain management, and central nervous system disorders. Samidorphan CAS NO 421552-35-4 represents a critical tool for advancing neuropharmacological studies.

Application

• Pharmaceutical Research: A key reference standard and active pharmaceutical ingredient (API) intermediate in the development of combination therapies for major depressive disorder and schizophrenia.
• Neuropharmacology Studies: Used in preclinical and clinical research to investigate the role of the opioid system in mood regulation, reward pathways, and substance use disorders.
• Analytical Development: Serves as a high-purity standard for method development and validation in quality control laboratories using HPLC, LC-MS, and other chromatographic techniques.
• Drug Discovery: Employed as a building block or target molecule in medicinal chemistry programs aiming to discover new opioid receptor modulators with improved efficacy and safety profiles.
• Clinical Trial Materials: Supplied as a GMP-grade material for the manufacture of formulations used in human clinical trials.

Basic Information

Product Name	Samidorphan
CAS No.	421552-35-4
Molecular Formula	C22H29NO4
Molecular Weight	371.47 g/mol
Synonyms	Samidorphan; (3R,4R)-7-Hydroxy-N-[(1S)-2-[(3R,4R)-4-(3-hydroxyphenyl)-3,4-dimethyl-1-piperidinyl]-1-methyl-2-oxoethyl]-1,2,3,4-tetrahydro-3-isoquinolinecarboxamide; ALKS 33; RDC-0313; RDC0313; RDC 0313; 1,2,3,4-Tetrahydro-7-hydroxy-N-[(1S)-1-methyl-2-oxo-2-[(3R,4R)-4-(3-hydroxyphenyl)-3,4-dimethyl-1-piperidinyl]ethyl]-3-isoquinolinecarboxamide
EINECS	Contact for details

Quality Control

Our Samidorphan is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including identification (IR, NMR), purity assay (HPLC), and control of specified impurities, to ensure it meets stringent pharmaceutical-grade standards. A Certificate of Analysis (COA) detailing all test results is provided with every shipment to guarantee traceability and compliance with your research or cGMP requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference standard
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0% Any single impurity ≤0.5%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.