Description

2-(3-Bromoazetidin-1-Yl)-Acetonitrile is a versatile and high-value azetidine-based building block, essential for advanced organic synthesis and pharmaceutical research. Its unique structure, featuring a reactive bromine atom and a nitrile group on a strained azetidine ring, makes it a critical intermediate for constructing complex nitrogen-containing heterocycles. This compound is primarily sought by research chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for developing new active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, particularly in medicinal chemistry programs targeting central nervous system (CNS) disorders, oncology, and infectious diseases.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides, leveraging its azetidine scaffold to modulate biological activity.
• Ligand and Catalyst Synthesis: Serves as a precursor for creating specialized ligands and catalysts used in asymmetric synthesis and transition metal catalysis.
• Chemical Biology Probes: Employed in the design and synthesis of molecular probes for studying enzyme function and biological pathways.
• Material Science: Potential monomer or cross-linking agent for creating polymers with specific thermal or mechanical properties.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the global life sciences sector.

Basic Information

Product Name	2-(3-Bromoazetidin-1-Yl)-Acetonitrile
CAS No.	420820-65-1
Molecular Formula	C5H7BrN2
Molecular Weight	175.03 g/mol
Synonyms	1-(Cyanomethyl)-3-bromoazetidine; 3-Bromo-1-(cyanomethyl)azetidine; Acetonitrile, 2-(3-bromo-1-azetidinyl)-; 3-Bromoazetidine-1-acetonitrile; Azetidine, 3-bromo-1-(cyanomethyl)-; (3-Bromoazetidin-1-yl)acetonitrile
EINECS	Contact for details

Quality Control

Our 2-(3-Bromoazetidin-1-Yl)-Acetonitrile is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, confirming compliance with customer specifications. Our quality commitment supports applications in cGMP (Current Good Manufacturing Practice) environments and research requiring the highest material integrity.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong acids and incompatible organic solvents. Due to its light-sensitive nature, containers should be kept in secondary packaging or amber glass/vials for long-term storage.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.