Description

2,2-Bis[(1R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethoxy]-1-(4-fluorophenyl)ethanone is a high-value, chiral fluorinated organic intermediate of significant interest in advanced chemical synthesis. This compound matters for its precise stereochemistry and the unique electronic properties imparted by its multiple trifluoromethyl and fluorine substituents, which are critical for modulating the biological activity and physicochemical characteristics of target molecules. It is primarily needed by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients, particularly where enhanced metabolic stability, bioavailability, and receptor binding affinity are required.

Application

• Pharmaceutical Intermediate: Serves as a key chiral building block in the synthesis of novel drug candidates, especially in oncology, CNS, and antiviral research.
• Agrochemical Synthesis: Used in the development of advanced pesticides and herbicides where fluorinated motifs improve efficacy and environmental stability.
• Catalyst Ligand Precursor: Its complex structure can be utilized to develop sophisticated chiral ligands for asymmetric catalysis.
• Material Science Research: Investigated for creating fluorinated polymers or advanced organic materials with specific optical or electronic properties.
• Process Chemistry & Scale-Up: Employed in route scouting and optimization for the commercial production of fine chemicals.
• Academic & Institutional Research: A valuable reagent for studying structure-activity relationships (SAR) and fluorination effects in organic chemistry.

Basic Information

Product Name	2,2-Bis[(1R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethoxy]-1-(4-fluorophenyl)ethanone
CAS No.	419574-40-6
Molecular Formula	C32H22F14O3
Molecular Weight	696.50 g/mol
Synonyms	1-(4-Fluorophenyl)-2,2-bis{[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]}ethanone; (R)-2,2-Bis[1-(3,5-bis(trifluoromethyl)phenyl)ethoxy]-1-(4-fluorophenyl)ethanone; CAS 419574-40-6; 2,2-Bis[(1R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethoxy]-1-(4-fluorophenyl)ethan-1-one; Chiral Fluorinated Diketone Derivative; α,α-Bis[(1R)-1-(3,5-bis(trifluoromethyl)phenoxy)]-4-fluoroacetophenone
EINECS	Contact for details

Quality Control

Our 2,2-Bis[(1R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethoxy]-1-(4-fluorophenyl)ethanone is produced under strict quality management systems to ensure batch-to-batch consistency and high purity, essential for sensitive synthetic applications. Each lot undergoes comprehensive analytical characterization including HPLC for chiral purity and assay, NMR for structural confirmation, and MS for identity verification. Certificates of Analysis (COA) detailing all specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its sensitivity to strong alkali and fluoride ions, keep away from such incompatible materials. For long-term storage, consider inert atmosphere conditions to preserve optimal quality.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.