Description

Aprepitant-M3 Metabolite is a key pharmacologically active metabolite of the antiemetic drug Aprepitant. This compound is of critical importance for pharmaceutical research and development, particularly in the study of drug metabolism, pharmacokinetics (PK), and bioanalytical method validation. It is primarily utilized by pharmaceutical companies, contract research organizations (CROs), and academic institutions engaged in the development and quality control of neurokinin-1 (NK1) receptor antagonists.

Application

• Reference Standard for Bioanalysis: Serves as a certified reference material (CRM) for the quantification of Aprepitant and its metabolites in biological matrices (plasma, serum) using LC-MS/MS.
• Drug Metabolism and Pharmacokinetics (DMPK) Studies: Essential for investigating the metabolic pathways, clearance mechanisms, and exposure levels of Aprepitant in preclinical and clinical studies.
• Impurity Profiling and Characterization: Used as an analytical standard to identify and quantify the M3 metabolite as a process-related or degradation impurity in Aprepitant active pharmaceutical ingredient (API) batches.
• Pharmacology Research: Supports studies aimed at understanding the individual contribution of metabolites to the overall efficacy and safety profile of Aprepitant.
• Regulatory Submission Support: Provides essential data for regulatory filings (e.g., FDA, EMA) to demonstrate comprehensive understanding of a drug's metabolic fate.
• Method Development and Validation: A critical component in developing, qualifying, and validating robust analytical methods for metabolite-specific assays.

Basic Information

Product Name	Aprepitant-M3 Metabolite
CAS No.	419574-04-2
Molecular Formula	C23H21F7N4O3
Molecular Weight	534.43 g/mol
Synonyms	5-[[(2R,3S)-2-[(1R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)-4-morpholinyl]methyl]-1,2-dihydro-3H-1,2,4-triazol-3-one; Aprepitant Metabolite M3; GW679769 (Metabolite); L-758,298 (Metabolite); MK-0869 Metabolite M3; (2R,3S)-2-[(1R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)-4-[(5-oxo-1,4-dihydro-1,2,4-triazol-3-yl)methyl]morpholine
EINECS	Contact for details

Quality Control

Our Aprepitant-M3 Metabolite is manufactured under strict quality control protocols suitable for research and analytical applications. Each batch is characterized using advanced spectroscopic and chromatographic techniques to ensure high purity and structural identity. Comprehensive Certificates of Analysis (COA) are provided, detailing results for assay, purity, and identification tests. We support compliance needs for GMP/GLP environments where applicable.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This product is hygroscopic (moisture-sensitive) and should be kept in a dry environment. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95.0%
Assay (HPLC)	97.0% - 102.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.