Description

Descyclopropyl Lenvatinib is a key pharmaceutical intermediate and metabolite of the active drug substance Lenvatinib. This compound is of significant value in the research, development, and quality control of oncology therapeutics. It is primarily utilized by pharmaceutical manufacturers, analytical laboratories, and research institutions engaged in the synthesis and impurity profiling of tyrosine kinase inhibitor drugs.

Application

• Pharmaceutical Intermediate: Critical building block in the synthesis and process development of Lenvatinib and related compounds.
• Reference Standard: Used as a certified reference material (CRM) for analytical method development, validation, and quality control testing of active pharmaceutical ingredients (APIs).
• Metabolite Studies: Employed in pharmacokinetic and drug metabolism research to understand the biotransformation pathways of Lenvatinib.
• Impurity Profiling: Serves as a specified impurity standard to monitor and control the quality of Lenvatinib API during manufacturing, ensuring compliance with ICH guidelines.
• Research & Development: Essential for academic and industrial R&D focused on novel tyrosine kinase inhibitors and cancer treatment mechanisms.

Basic Information

Product Name	Descyclopropyl Lenvatinib
CAS No.	417719-51-8
Molecular Formula	C20H19ClN4O4
Molecular Weight	414.84 g/mol
Synonyms	Lenvatinib Impurity; Lenvatinib Descyclopropyl; Lenvatinib Metabolite; 4-[3-Chloro-4-[(cyclopropylcarbamoyl)amino]phenoxy]-7-methoxyquinoline-6-carboxamide derivative; E7080 Descyclopropyl; N-[3-Chloro-4-[[(cyclopropylamino)carbonyl]amino]phenoxy]-7-methoxy-6-quinolinecarboxamide derivative; Lenvatinib Related Compound
EINECS	Contact for details

Quality Control

Our Descyclopropyl Lenvatinib is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC purity, identity confirmation (IR, MS), and residual solvent analysis, to ensure it meets the stringent requirements for pharmaceutical reference standards and intermediates. Certificates of Analysis (COA) with detailed chromatographic data are provided and can be tailored to support regulatory filings (e.g., ICH Q3B, FDA/EMA submissions).

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single unknown impurity ≤ 0.5%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.