Description

Di-tert-Butyl(2-Dimethylaminophenyl)Phosphine is a specialized, sterically hindered phosphine ligand that is crucial for enabling highly efficient and selective transition metal-catalyzed reactions. Its unique electronic and steric properties make it an indispensable tool for researchers and process chemists developing advanced synthetic methodologies. This compound is primarily utilized in the pharmaceutical, agrochemical, and fine chemical industries for applications such as cross-coupling, hydrogenation, and hydrofunctionalization reactions.

Application

• As a highly effective ligand in palladium-catalyzed cross-coupling reactions (e.g., Suzuki-Miyaura, Buchwald-Hartwig amination).
• For catalyst development in asymmetric synthesis and chiral molecule production for active pharmaceutical ingredients (APIs).
• In academic and industrial R&D for exploring new catalytic cycles and reaction mechanisms.
• As a key component in catalyst systems for the synthesis of complex agrochemical intermediates.
• For fine chemical synthesis where high selectivity and yield are paramount.
• In material science research, particularly in the development of novel organometallic complexes.

Basic Information

Product Name	Di-tert-Butyl(2-Dimethylaminophenyl)Phosphine
CAS No.	415941-58-1
Molecular Formula	C16H28NP
Molecular Weight	265.38 g/mol
Synonyms	DTB-DMAPPh; 2-(Dimethylamino)phenyldi-tert-butylphosphine; Di-tert-butyl[2-(dimethylamino)phenyl]phosphane; Di-tert-butyl(2-dimethylaminophenyl)phosphane; (2-(Dimethylamino)phenyl)di-tert-butylphosphine; Di-tert-butyl-(2-dimethylaminophenyl)phosphine; Di-tert-butyl(2-(dimethylamino)phenyl)phosphine; Ligand for Buchwald-Hartwig amination
EINECS	Contact for details

Quality Control

Our production of Di-tert-Butyl(2-Dimethylaminophenyl)Phosphine adheres to stringent internal quality standards to ensure batch-to-batch consistency and high purity, which is critical for catalytic performance. Every lot is characterized by NMR (1H, 13C, 31P) and HPLC analysis. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with each shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Due to its sensitivity to oxidation, this material should be stored under an inert atmosphere (argon or nitrogen) in a cool, dry place. Recommended long-term storage temperature is 2-8°C. Allow the container to reach room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
31P NMR Purity	≥ 98.0%
Solubility	Soluble in common organic solvents (THF, toluene, dichloromethane)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.