Description

(S)-(+)-(3,5-Dioxa-4-Phospha-Cyclohepta[2,1-A:3,4-A']Dinaphthalen-4-Yl)Bis[(1R)-1-Phenylethyl]Amine,Dichloromethane Adduct is a high-purity, chiral organophosphorus ligand complex, specifically designed for asymmetric catalysis. This compound is a critical reagent for enabling highly enantioselective transformations, offering researchers and process chemists a powerful tool for constructing complex chiral molecules. It is primarily utilized in advanced pharmaceutical synthesis, agrochemical research, and the development of specialty materials where precise stereochemical control is paramount.

Application

• Asymmetric Hydrogenation Catalysis: Employed as a chiral ligand for the enantioselective reduction of prochiral olefins, ketones, and imines in pharmaceutical intermediate synthesis.
• Pharmaceutical Intermediate Manufacturing: Key component in the synthesis of active pharmaceutical ingredients (APIs) requiring high enantiomeric purity, such as chiral amines and alcohols.
• Agrochemical Research & Development: Used to create enantiomerically pure herbicides, fungicides, and plant growth regulators with optimized activity and environmental profiles.
• Fine Chemical Production: Facilitates asymmetric C-C and C-X bond-forming reactions for the production of specialty flavors, fragrances, and advanced materials.
• Academic & Process Chemistry Research: A valuable tool for developing new catalytic methodologies and exploring novel reaction pathways in asymmetric synthesis.
• Ligand Screening Libraries: Serves as a benchmark or component in high-throughput screening for discovering new catalytic systems.

Basic Information

Product Name	(S)-(+)-(3,5-Dioxa-4-Phospha-Cyclohepta[2,1-A:3,4-A']Dinaphthalen-4-Yl)Bis[(1R)-1-Phenylethyl]Amine,Dichloromethane Adduct
CAS No.	415918-91-1
Molecular Formula	C41H37NO2P · CH2Cl2
Molecular Weight	Contact for details
Synonyms	(S)-BINAPO; (S)-2,2'-Bis(diphenylphosphino)-1,1'-binaphthyl dioxide; (S)-BINAP dioxide; (S)-(+)-2,2'-Bis(diphenylphosphino)-1,1'-binaphthyl 5,5'-dioxide; (S)-Bis(1-phenylethyl)amine adduct of BINAP dioxide; (S)-H8-BINAPO; (S)-BINAP Monoxide (common misnomer); Ligand (S)-BINAPO Dichloromethane Solvate
EINECS	Contact for details

Quality Control

Our (S)-(+)-(3,5-Dioxa-4-Phospha-Cyclohepta[2,1-A:3,4-A']Dinaphthalen-4-Yl)Bis[(1R)-1-Phenylethyl]Amine,Dichloromethane Adduct is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing including HPLC for chiral purity and chemical assay, NMR for structural confirmation, and residual solvent analysis to ensure compliance with stringent specifications for research and process use. A detailed Certificate of Analysis (COA) is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C) under an inert atmosphere (e.g., nitrogen or argon) due to its sensitivity to moisture and oxidation. Keep the container tightly sealed to prevent loss of the dichloromethane solvate and exposure to air.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Loss on Drying	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.