Description

Neuropeptide S (Human) CAS NO 412938-67-1 is a bioactive neuropeptide that functions as a potent modulator of arousal, anxiety, and stress responses by activating the G protein-coupled receptor NPSR1. Its primary commercial value lies in its critical role as a high-purity reference standard and active ingredient for advanced neuroscience research and pharmaceutical development. This product is essential for biotechnology firms, academic research institutions, and pharmaceutical companies focused on developing novel therapeutics for anxiety disorders, sleep-wake regulation, and addiction.

Application

• Neuroscience Research: Used as a key reference standard and tool compound for studying the NPS/NPSR1 system, neuronal excitability, and behavioral pharmacology.
• Drug Discovery & Development: Serves as a critical starting material or intermediate in the synthesis and screening of novel anxiolytic, wake-promoting, or anti-addiction drug candidates.
• Biochemical Assay Development: Employed in the development and validation of high-throughput screening (HTS) assays, receptor binding studies, and functional cellular assays.
• In Vitro & In Vivo Studies: Utilized in experimental models to investigate its effects on locomotor activity, anxiety-like behavior, fear conditioning, and stress responses.
• Peptide Chemistry & Synthesis: Acts as a benchmark for peptide synthesis optimization, purity analysis, and structural confirmation in process development.
• Diagnostic Tool Manufacturing: Can be incorporated into specialized diagnostic kits and reagents for research into neuropsychiatric conditions.

Basic Information

Product Name	Neuropeptide S (Human)
CAS No.	412938-67-1
Molecular Formula	C₈₀H₁₂₈N₂₄O₂₅S₂
Molecular Weight	1882.1 g/mol
Synonyms	Neuropeptide S; NPS; Human Neuropeptide S; SFRNGVGSGVKKTSFRRAKQ; Neuropeptide S (1-20), human; NPS, human; H-Ser-Phe-Arg-Asn-Gly-Val-Gly-Ser-Gly-Val-Lys-Lys-Thr-Ser-Phe-Arg-Arg-Ala-Lys-Gln-OH
EINECS	Contact for details

Quality Control

Every batch of Neuropeptide S (Human) is manufactured and analyzed under strict quality management systems to ensure the highest standards of purity and consistency for research and development. Our products undergo rigorous quality testing, including multiple orthogonal analytical methods, to ensure identity, purity, and biological activity. A comprehensive Certificate of Analysis (COA) detailing purity (by HPLC), peptide content, amino acid analysis, and mass spectrometry (MS) data is provided with each shipment to guarantee traceability and compliance with your project requirements.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a dry environment before opening to prevent condensation and moisture uptake. For optimal results, aliquot into single-use quantities to avoid repeated freeze-thaw cycles.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC & MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80% (by amino acid analysis)
Molecular Weight	1882.1 ± 1.0 Da (by mass spectrometry)
Solubility	Soluble in water or dilute acetic acid
Single Impurity (HPLC)	≤ 1.0%
Water Content (KF)	≤ 5.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.