Description

Succinic Anhydride-13C4 is a stable isotope-labeled derivative of succinic anhydride, where all four carbon atoms are the carbon-13 (13C) isotope. This compound is essential as a high-purity internal standard and tracer in quantitative mass spectrometry and nuclear magnetic resonance (NMR) spectroscopy, providing unparalleled accuracy for metabolic flux analysis and pharmacokinetic studies. It is a critical material for researchers and manufacturers in the pharmaceutical, biotechnology, and agrochemical industries developing and validating analytical methods.

Application

• Quantitative Mass Spectrometry (MS): Serves as a precise internal standard for the absolute quantification of endogenous succinate and related metabolites in complex biological matrices like plasma, urine, and tissue extracts.
• Metabolic Pathway Tracing (13C Flux Analysis): Used to trace and quantify metabolic fluxes in central carbon metabolism (e.g., TCA cycle) within cells, tissues, or whole organisms to study disease states or engineered pathways.
• Nuclear Magnetic Resonance (NMR) Spectroscopy: Acts as a 13C-enriched starting material or reference compound for synthesizing labeled probes, enabling detailed structural and dynamic studies of biomolecules.
• Pharmaceutical Drug Metabolism & Pharmacokinetics (DMPK): Employed in the synthesis of isotopically labeled drug candidates to facilitate accurate tracking of drug absorption, distribution, metabolism, and excretion (ADME) in preclinical and clinical research.
• Diagnostic Assay Development: Used in the calibration and validation of clinical diagnostic assays for inborn errors of metabolism, where succinate levels are a key biomarker.
• Synthesis of Labeled Compounds: A key building block for the synthesis of more complex 13C-labeled fine chemicals, polymers, or active pharmaceutical ingredients (APIs) for research purposes.

Basic Information

Product Name	Succinic Anhydride-13C4
CAS No.	411220-47-8
Molecular Formula	13C4H4O3
Molecular Weight	104.03 (for 13C4)
Synonyms	Butanedioic Anhydride-13C4; Dihydro-2,5-furandione-13C4; Succinic Acid Anhydride-13C4; 2,5-Diketotetrahydrofuran-13C4; Tetrahydro-2,5-dioxofuran-13C4; [13C4]-Succinic Anhydride; 13C4-Succinic Anhydride
EINECS	Contact for details

Quality Control

Our Succinic Anhydride-13C4 is manufactured under controlled conditions to ensure the highest isotopic and chemical purity required for sensitive analytical applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing isotopic enrichment (Atom % 13C), chemical purity, and identity confirmation via spectroscopic methods. We adhere to stringent quality management practices to guarantee batch-to-batch consistency and reliability for your research and development needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive). For long-term storage, consider storing under an inert atmosphere in a desiccator to maintain stability and isotopic integrity.

Specification

Item	Specification
Appearance	White to off-white crystalline solid
Identification (IR)	Conforms to structure
Isotopic Enrichment (Atom % 13C)	≥ 99%
Chemical Purity (HPLC)	≥ 98%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.