Description

Palovarotene CAS NO 410528-02-8 is a highly potent and selective retinoic acid receptor gamma (RARγ) agonist. This small molecule pharmaceutical compound is critical for its targeted therapeutic action in modulating specific cellular pathways. It is primarily required by pharmaceutical research organizations and manufacturers developing treatments for rare bone disorders and other conditions involving abnormal bone formation. Our supply ensures the high purity and consistency essential for preclinical and clinical development.

Application

• Pharmaceutical Active Ingredient (API): Core component in the formulation of investigational and approved therapeutics.
• Research and Development (R&D): Used in biochemical and pharmacological studies to investigate RARγ-mediated signaling pathways.
• Preclinical Studies: Essential for in vitro and in vivo testing to establish efficacy and safety profiles.
• Clinical Trial Material (CTM) Manufacturing: Sourced for the production of drug products used in human clinical trials.
• Reference Standard: Serves as a high-purity benchmark for analytical method development and quality control testing.
• Drug Discovery: A key compound for exploring new therapeutic applications in fibrodysplasia ossificans progressiva (FOP) and related heterotopic ossification disorders.

Basic Information

Product Name	Palovarotene
CAS No.	410528-02-8
Molecular Formula	C₂₄H₂₈O₄
Molecular Weight	380.48 g/mol
Synonyms	R 667; RO-3300074; 4-[[(5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)carbamoyl]benzoic acid; 4-[(5,5,8,8-Tetramethyl-5,6,7,8-tetrahydronaphthalene-2-carbonyl)amino]benzoic acid; Palovarotene Hydrochloride (salt form); RARγ agonist R667
EINECS	Contact for details

Quality Control

Our Palovarotene is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including identity confirmation by spectroscopic methods (IR, NMR), purity assessment by HPLC, and control of specified impurities. A Certificate of Analysis (COA) detailing all test results is provided with every shipment to ensure full traceability and compliance with your research or cGMP requirements.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at controlled room temperature (15-25°C) or as specified on the label. The material is light-sensitive and easily oxidized; prolonged exposure to air or light should be avoided to maintain stability and potency.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0% Any single impurity ≤0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤0.5%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.