Description

2,5-Difluorobenzeneboronic Acid Pinacol Ester is a high-purity, organoboron building block essential for modern synthetic chemistry. Its primary value lies in enabling efficient Suzuki-Miyaura cross-coupling reactions, a cornerstone method for constructing complex biaryl and heterobiaryl structures. This compound is critically needed by R&D and process chemists in the pharmaceutical, agrochemical, and advanced materials industries for the development of new active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: A key synthon for constructing fluorinated drug candidates, including kinase inhibitors and active pharmaceutical ingredients (APIs).
• Agrochemical Synthesis: Used in the production of novel herbicides, fungicides, and pesticides with enhanced properties.
• Material Science: Serves as a precursor for creating fluorinated organic electronic materials, such as OLEDs and semiconductors.
• Chemical Research: Fundamental building block in academic and industrial laboratories for methodology development and library synthesis.
• Ligand & Catalyst Development: Employed in the synthesis of novel bidentate ligands and metal-organic frameworks (MOFs).
• Fluorine Chemistry: Utilized to introduce the 2,5-difluoro substitution pattern into complex molecular architectures.

Basic Information

Item	Detail
Product Name	2,5-Difluorobenzeneboronic Acid Pinacol Ester
CAS No.	408492-25-1
Molecular Formula	C12H15BF2O2
Molecular Weight	240.06 g/mol
Synonyms	2,5-Difluorophenylboronic Acid Pinacol Ester; (2,5-Difluorophenyl)boronic Acid Pinacol Ester; 4,4,5,5-Tetramethyl-2-(2,5-difluorophenyl)-1,3,2-dioxaborolane; 2-(2,5-Difluorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; Pinacol 2,5-Difluorophenylboronate; 2,5-Difluorobenzeneboronic Acid Neopentyl Glycol Ester (common alternative); B-(2,5-Difluorophenyl)boronic Acid Pinacol Ester
EINECS	Contact for details

Quality Control

Our 2,5-Difluorobenzeneboronic Acid Pinacol Ester is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity, suitable for demanding synthetic applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP principles where applicable and can support regulatory filings.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and decomposition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.