Description

4-Nitro-2-(Trifluoromethyl)Phenylboronic Acid is a specialized organoboron compound that serves as a critical building block in modern synthetic chemistry. Its value lies in enabling the precise construction of complex molecular architectures, particularly those containing the pharmacologically important trifluoromethyl and nitro functional groups. This high-purity intermediate is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries developing new active ingredients.

Application

This versatile boronic acid derivative is primarily employed as a key synthetic intermediate in cross-coupling reactions.

• Pharmaceutical Intermediate: A crucial building block for the synthesis of novel active pharmaceutical ingredients (APIs), especially those targeting central nervous system (CNS) disorders, inflammation, and infectious diseases.
• Agrochemical Synthesis: Used in creating advanced herbicides, fungicides, and insecticides where the trifluoromethyl group enhances biological activity and environmental stability.
• Material Science Research: Serves as a monomer or precursor for developing advanced organic electronic materials, such as OLEDs and semiconductors.
• Suzuki-Miyaura Cross-Coupling: The principal application is in palladium-catalyzed Suzuki reactions to form biaryl and heterobiaryl structures, which are common scaffolds in medicinal chemistry.
• Ligand and Catalyst Development: Utilized in the preparation of specialized ligands for catalysis and metal-organic frameworks (MOFs).
• Chemical Biology Probes: Acts as a precursor for fluorescent tags and molecular probes used in diagnostic and bioimaging applications.

Basic Information

Product Name	4-Nitro-2-(Trifluoromethyl)Phenylboronic Acid
CAS No.	408359-15-9
Molecular Formula	C7H5BF3NO4
Molecular Weight	234.93 g/mol
Synonyms	[4-Nitro-2-(trifluoromethyl)phenyl]boronic acid; 2-Trifluoromethyl-4-nitrophenylboronic acid; (4-Nitro-2-trifluoromethylphenyl)boronic acid; 4-Nitro-2-trifluoromethylbenzeneboronic acid; Boronic acid, B-[4-nitro-2-(trifluoromethyl)phenyl]-; 408359-15-9; 4-Nitro-α,α,α-trifluoro-o-tolylboronic acid.
EINECS	Contact for details

Quality Control

Our 4-Nitro-2-(Trifluoromethyl)Phenylboronic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity and consistency, meeting the exacting standards required for research and commercial-scale synthesis. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 20 ppm
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.