Description

2-Trifluoromethyl-6-Nitrophenylboronic Acid is a high-value, multi-functional boronic acid derivative that serves as a critical building block in modern synthetic chemistry. Its unique structure, featuring both a nitro and a trifluoromethyl group, makes it an essential reagent for constructing complex molecules with tailored electronic and steric properties. This compound is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for applications such as Suzuki-Miyaura cross-coupling reactions.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for compounds requiring fluorinated aromatic systems.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and insecticides where the trifluoromethyl group enhances biological activity and metabolic stability.
• Material Science Research: Employed in the creation of novel organic electronic materials, such as OLEDs and semiconductors, due to its electron-withdrawing characteristics.
• Suzuki-Miyaura Cross-Coupling: Serves as a versatile boronic acid partner for forming carbon-carbon bonds in complex molecule assembly, a cornerstone of modern medicinal chemistry.
• Ligand and Catalyst Development: Utilized in the design and synthesis of novel ligands for catalysis and molecular recognition applications.
• Chemical Biology Probes: Acts as a building block for creating fluorescent tags and other molecular probes used in biochemical research and diagnostics.

Basic Information

Product Name	2-Trifluoromethyl-6-Nitrophenylboronic Acid
CAS No.	408359-14-8
Molecular Formula	C7H5BF3NO4
Molecular Weight	234.93 g/mol
Synonyms	(2-Nitro-6-(trifluoromethyl)phenyl)boronic acid; 2-Nitro-6-(trifluoromethyl)benzeneboronic acid; B-[2-Nitro-6-(trifluoromethyl)phenyl]boronic acid; 2-(Trifluoromethyl)-6-nitrobenzeneboronic acid; 408359-14-8; Boronic acid, B-[2-nitro-6-(trifluoromethyl)phenyl]-; 2-CF3-6-NO2-PhB(OH)2
EINECS	Contact for details

Quality Control

Our 2-Trifluoromethyl-6-Nitrophenylboronic Acid is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the high standards required for research and process chemistry. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.