Description

Bicyclo[3.1.0]Hexane, 1-(Bromoethynyl)-2-Methylene-, (1R,5R)- (9Ci) is a highly specialized chiral bicyclic building block featuring a reactive bromoethynyl group and an exocyclic methylene unit. This compound is valued for its unique three-dimensional structure and functional handles, enabling the synthesis of complex, strained molecular architectures. It is primarily sought after by research chemists and process development scientists in the pharmaceutical and agrochemical industries for applications in medicinal chemistry, asymmetric synthesis, and the development of novel bioactive compounds.

Application

• Pharmaceutical Intermediate: A key chiral synthon for constructing complex, strained-ring systems found in active pharmaceutical ingredients (APIs).
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to explore novel chemical space.
• Agrochemical Synthesis: Serves as a building block for developing new pesticides and herbicides with unique modes of action.
• Material Science Precursor: Potential use in synthesizing advanced polymers or ligands with specific steric and electronic properties.
• Asymmetric Catalysis: Employed in the development of novel chiral catalysts or ligands due to its rigid, three-dimensional framework.
• Chemical Biology Probes: Useful for creating molecular probes to study enzyme mechanisms or protein-ligand interactions.

Basic Information

Product Name	Bicyclo[3.1.0]Hexane, 1-(Bromoethynyl)-2-Methylene-, (1R,5R)- (9Ci)
CAS No.	406457-45-2
Molecular Formula	C9H7Br
Molecular Weight	195.06 g/mol
Synonyms	(1R,5R)-1-(Bromoethynyl)-2-methylidenebicyclo[3.1.0]hexane; 1-(Bromoethynyl)-2-methylidenebicyclo[3.1.0]hexane, (1R,5R)-; (1R,5R)-1-(2-Bromoethynyl)-2-methylidenebicyclo[3.1.0]hexane; Bicyclo[3.1.0]hexane, 1-(bromoethynyl)-2-methylene-, (1R,5R)-; (1R,5R)-1-(Bromoethynyl)-2-methylenebicyclo[3.1.0]hexane; 406457-45-2; (1R,5R)-1-(Bromoethynyl)-2-methylene-bicyclo[3.1.0]hexane
EINECS	Contact for details

Quality Control

Our Bicyclo[3.1.0]Hexane, 1-(Bromoethynyl)-2-Methylene-, (1R,5R)- (9Ci) is manufactured under strict quality management protocols. Each batch undergoes rigorous analytical testing, including chiral purity analysis, to ensure high chemical and isomeric purity suitable for advanced synthetic applications. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area. For long-term storage, it is recommended to keep the material under an inert atmosphere at temperatures between 2°C and 8°C to maintain stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.