Description

1-(1-Bromoethyl)-2-Fluorobenzene is a versatile fluorinated and brominated aromatic building block of significant interest in advanced organic synthesis. Its bifunctional nature, featuring both a reactive benzylic bromide and a fluorine substituent, makes it a critical intermediate for constructing complex molecular architectures. This compound is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the development of novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of fluorinated drug candidates, particularly in medicinal chemistry programs targeting CNS disorders and oncology.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where the fluorine atom enhances biological activity and metabolic stability.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized phosphine or nitrogen-based ligands used in asymmetric catalysis and cross-coupling reactions.
• Material Science Research: Employed in the synthesis of fluorinated liquid crystals, polymers, and organic electronic materials to modify dielectric properties and stability.
• Cross-Coupling Reactions: The benzylic bromide moiety is reactive in various metal-catalyzed cross-couplings (e.g., Suzuki, Negishi) for carbon-carbon bond formation.
• Fluorine Chemistry Studies: Acts as a model substrate for investigating the electronic and steric effects of ortho-fluorine substitution on benzylic reaction centers.

Basic Information

Product Name	1-(1-Bromoethyl)-2-Fluorobenzene
CAS No.	405931-46-6
Molecular Formula	C8H8BrF
Molecular Weight	203.05 g/mol
Synonyms	1-(1-Bromoethyl)-2-fluorobenzene; 1-Bromo-1-(2-fluorophenyl)ethane; (2-Fluorophenyl)methyl bromide; α-Bromo-o-fluoroethylbenzene; 2-Fluoro-α-bromoethylbenzene; 1-(2-Fluorophenyl)ethyl bromide; o-Fluoro-α-bromoethylbenzene; (1-Bromoethyl)-2-fluorobenzene
EINECS	Contact for details

Quality Control

Our 1-(1-Bromoethyl)-2-Fluorobenzene is manufactured under strict quality management protocols to ensure batch-to-batch consistency and high purity for research and development applications. Each lot is characterized using advanced analytical techniques including GC, HPLC, NMR, and MS to confirm identity and purity. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from strong acids, bases, and oxidizing agents. For long-term storage under inert atmosphere, please contact our technical team for specific recommendations.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.