Description

4,4-Bis(Trifluoromethyl)-2,4-Dihydro-2-Methyl-1H-Benzo[D][1,3]Oxazine is a specialized heterocyclic compound featuring a benzoxazine core substituted with two trifluoromethyl groups, making it a valuable fluorinated building block for advanced material science and pharmaceutical research. Its unique structure provides exceptional chemical stability and lipophilicity, which are critical for developing high-performance polymers, liquid crystals, and active pharmaceutical ingredients (APIs). This compound is essential for R&D chemists and process engineers in the agrochemical, pharmaceutical, and specialty polymer industries seeking to incorporate fluorine chemistry for enhanced product properties.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders, due to the ability of the trifluoromethyl groups to improve metabolic stability and membrane permeability.
• Agrochemical Synthesis: Used in the development of next-generation herbicides and pesticides, where the fluorine atoms contribute to increased biological activity and environmental persistence.
• Advanced Material Precursor: A critical monomer for synthesizing high-performance, fluorinated polybenzoxazines, which exhibit excellent thermal stability, low surface energy, and superior dielectric properties for electronics and aerospace coatings.
• Liquid Crystal Formulations: Acts as a core component in the design of fluorinated liquid crystals for display technologies, offering improved optical anisotropy and response times.
• Organic Synthesis Building Block: Provides a versatile scaffold for constructing complex, fluorinated organic molecules in academic and industrial research laboratories.
• Specialty Chemical Manufacturing: Employed in the production of fluorinated surfactants, additives, and dyes that require specific solubility and stability profiles.

Basic Information

Product Name	4,4-Bis(Trifluoromethyl)-2,4-Dihydro-2-Methyl-1H-Benzo[D][1,3]Oxazine
CAS No.	405919-98-4
Molecular Formula	C12H9F6NO
Molecular Weight	297.20 g/mol
Synonyms	2-Methyl-4,4-bis(trifluoromethyl)-1,4-dihydro-2H-3,1-benzoxazine; 2-Methyl-4,4-bis(trifluoromethyl)-3,1-benzoxazine; 4,4-Bis(trifluoromethyl)-2-methyl-3,4-dihydro-2H-1,3-benzoxazine; 2-Methyl-4,4-bis(trifluoromethyl)-3,4-dihydro-2H-1,3-benzoxazine; 4,4-Bis(trifluoromethyl)-2-methyl-2H-1,3-benzoxazine; 405919-98-4; Benzoxazine, 4,4-bis(trifluoromethyl)-2,4-dihydro-2-methyl-
EINECS	Contact for details

Quality Control

Every batch of 4,4-Bis(Trifluoromethyl)-2,4-Dihydro-2-Methyl-1H-Benzo[D][1,3]Oxazine is manufactured and tested under a strict quality management system. We employ advanced analytical techniques including HPLC, GC, NMR, and MS to ensure high purity and batch-to-batch consistency, meeting the stringent requirements for research and scale-up applications. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to support your quality assurance and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep the container tightly sealed in a dry environment to minimize exposure to moisture. Handle and store in accordance with all applicable local and international regulations for industrial chemicals.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.