Description

n-(2,2,2-Trifluoroethyl)Benzenemethanamine Hydrochloride is a high-purity, specialty organic salt compound with the CAS number 405878-98-0, serving as a critical building block in advanced pharmaceutical and agrochemical synthesis. Its value lies in the unique trifluoroethylamine moiety, which is instrumental for modulating the biological activity, metabolic stability, and lipophilicity of target molecules. This intermediate is essential for research and development chemists and process scale-up teams in the pharmaceutical, agrochemical, and advanced materials sectors seeking to introduce fluorine-containing pharmacophores.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and antiviral drug candidates.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides where the trifluoroethyl group enhances efficacy and environmental stability.
• Ligand and Catalyst Preparation: Serves as a precursor for chiral ligands or catalysts used in asymmetric synthesis and other specialized organic transformations.
• Fluorine Chemistry Research: A valuable compound for academic and industrial research focused on incorporating fluorine atoms into complex organic architectures to study structure-activity relationships.
• Fine Chemical Production: Employed in the multi-step synthesis of other high-value, fluorine-containing fine chemicals and specialty materials.

Basic Information

Product Name	n-(2,2,2-Trifluoroethyl)Benzenemethanamine Hydrochloride
CAS No.	405878-98-0
Molecular Formula	C9H11ClF3N
Molecular Weight	225.64 g/mol
Synonyms	Benzyl(2,2,2-trifluoroethyl)amine hydrochloride; N-Benzyl-2,2,2-trifluoroethanamine hydrochloride; 1-(Phenylmethyl)-2,2,2-trifluoroethylamine hydrochloride; α-(Trifluoroethyl)benzylamine hydrochloride; N-(2,2,2-Trifluoroethyl)benzylamine HCl; (2,2,2-Trifluoroethyl)(phenylmethyl)amine hydrochloride; 405878-98-0; N-(Trifluoroethyl)benzylamine hydrochloride
EINECS	Contact for details

Quality Control

Our n-(2,2,2-Trifluoroethyl)Benzenemethanamine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and FTIR, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with every shipment, confirming compliance with agreed specifications. Our quality commitment supports applications requiring high standards, including cGMP development and commercial scale production.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after initial opening to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.