Description

3-(2-Tetrazolyl)-L-Alanine is a specialized non-proteinogenic amino acid derivative featuring a tetrazole heterocycle. This unique structure makes it a valuable building block in medicinal chemistry and pharmaceutical research, particularly for the design of peptidomimetics and enzyme inhibitors. It is primarily utilized by research institutions and pharmaceutical companies engaged in drug discovery and development, especially for projects targeting metabolic and cardiovascular diseases.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of novel drug candidates, particularly angiotensin II receptor antagonists and other bioactive peptides.
• Medicinal Chemistry Research: Serves as a constrained amino acid analog for studying protein-ligand interactions and developing peptidomimetic compounds.
• Bioconjugation & Probe Development: The tetrazole moiety can be utilized in bioorthogonal chemistry for labeling and imaging applications.
• Chemical Biology Tool: Used to incorporate specific functional groups into peptides to modulate their stability, activity, and receptor selectivity.
• Reference Standard: Employed as an analytical standard in quality control laboratories for method development and validation.

Basic Information

Product Name	3-(2-Tetrazolyl)-L-Alanine
CAS No.	405150-16-5
Molecular Formula	C₄H₇N₅O₂
Molecular Weight	157.13 g/mol
Synonyms	L-3-(2H-Tetrazol-5-yl)alanine; (S)-2-Amino-3-(1H-tetrazol-5-yl)propanoic acid; 3-(1H-Tetrazol-5-yl)-L-alanine; 5-(1-Amino-2-carboxyethyl)-1H-tetrazole; Tetrazole-L-alanine; Fmoc-3-(2-Tetrazolyl)-L-alanine derivative (precursor)
EINECS	Contact for details

Quality Control

Our 3-(2-Tetrazolyl)-L-Alanine is produced under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC for purity and chiral integrity, to ensure it meets the high standards required for research and development. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming identity, purity, and other critical parameters.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This compound is hygroscopic (moisture-sensitive); keep the container tightly sealed in a desiccated environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% (L-isomer)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.