Description

15-Keto Travoprost is a key pharmaceutical intermediate and metabolite of the active pharmaceutical ingredient Travoprost. This compound is of significant importance in the research, development, and quality control of prostaglandin analog-based ophthalmic solutions. It is primarily required by pharmaceutical manufacturers, analytical laboratories, and research institutions involved in the synthesis of advanced glaucoma medications and the development of related analytical methods.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of Travoprost and related prostaglandin analogs.
• Reference Standard: Used as a certified reference material (CRM) for analytical method development, validation, and quality control testing of active pharmaceutical ingredients (APIs) and finished drug products.
• Metabolite Studies: Employed in pharmacokinetic and pharmacodynamic research to study the metabolism and biological activity of Travoprost.
• Impurity Profiling: Serves as a known impurity standard to monitor and control the quality of Travoprost API during manufacturing, ensuring compliance with ICH guidelines.
• Biochemical Research: Utilized in investigative studies targeting the FP prostanoid receptor to understand mechanisms of intraocular pressure regulation.
• Process Development: Applied in the optimization and scale-up of synthetic routes for prostaglandin-based therapeutics.

Basic Information

Product Name	15-Keto Travoprost
CAS No.	404830-45-1
Molecular Formula	C₂₆H₃₅F₃O₆
Molecular Weight	500.55 g/mol
Synonyms	15-Oxo Travoprost; Travoprost Impurity; (5Z)-7-[(1R,2R,3R,5S)-3,5-Dihydroxy-2-[(1E,3R)-3-hydroxy-4-[3-(trifluoromethyl)phenoxy]-1-buten-1-yl]cyclopentyl]-5-heptenoic Acid; 15-Ketotravoprost; Prosta-5,13-dien-1-oic acid, 9,11,15-trihydroxy-17-phenyl-18,19,20-trinor-16-(3-trifluoromethylphenoxy)-, (5Z,9α,11α,13E,15R,17S)-; AL-6221 metabolite
EINECS	Contact for details

Quality Control

Our 15-Keto Travoprost is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, identity confirmation by IR and MS, and control of specified impurities. We provide Certificates of Analysis (COA) with detailed results, ensuring traceability and compliance with cGMP and ICH Q3 guidelines for pharmaceutical impurities.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under inert conditions (e.g., nitrogen atmosphere) for long-term storage to prevent degradation. Keep the container tightly sealed in a desiccator after opening.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Individual impurity: ≤ 0.5% Total impurities: ≤ 2.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.