Description

4,4'-Bis(T-Butyl)-1,1',2,2'-Tetrakis(Diphenylphosphino)Ferrocene, 98% Hiersophos-5 is a high-purity, sterically hindered ferrocene-based diphosphine ligand, widely recognized for its exceptional performance in asymmetric catalysis. This compound matters because it provides superior chiral induction and stability under demanding reaction conditions, enabling the synthesis of complex, enantiomerically pure molecules. It is an essential tool for R&D chemists and process engineers in the pharmaceutical, agrochemical, and fine chemical industries who require high selectivity and yield in cross-coupling and hydrogenation reactions.

Application

• Asymmetric Hydrogenation: A premier ligand for the enantioselective hydrogenation of prochiral olefins, ketones, and imines, critical for producing chiral intermediates in active pharmaceutical ingredients (APIs).
• Cross-Coupling Reactions: Facilitates challenging C-C and C-X bond-forming reactions, such as Suzuki-Miyaura and Buchwald-Hartwig couplings, with high turnover numbers.
• Pharmaceutical Synthesis: Used in the development and scale-up of chiral drugs, where precise stereochemical control is paramount for efficacy and regulatory approval.
• Agrochemical Manufacturing: Enables the production of enantiomerically pure herbicides, fungicides, and pesticides with improved activity and environmental profiles.
• Advanced Material Research: Serves as a building block or catalyst in the synthesis of chiral polymers and functional materials with specific optical or electronic properties.
• Academic & Industrial R&D: A valuable reagent for methodological development in organic synthesis and catalysis within university and corporate research laboratories.

Basic Information

Product Name	4,4'-Bis(T-Butyl)-1,1',2,2'-Tetrakis(Diphenylphosphino)Ferrocene, 98% Hiersophos-5
CAS No.	403815-19-0
Molecular Formula	C66H68FeP4
Molecular Weight	1045.90 g/mol
Synonyms	Hiersophos-5; 4,4'-Di-tert-butyl-1,1',2,2'-tetrakis(diphenylphosphino)ferrocene; 4,4'-Bis(tert-butyl)-1,1',2,2'-tetrakis(diphenylphosphino)ferrocene; 4,4'-Di-t-butyl-1,1',2,2'-tetrakis(diphenylphosphino)ferrocene; (R)-(+)-4,4'-Bis(1,1-dimethylethyl)-1,1',2,2'-tetrakis(diphenylphosphino)ferrocene; (R)-4,4'-Di-tert-butyl-1,1',2,2'-tetrakis(diphenylphosphino)ferrocene; (R)-DTB-TPF; (R)-Hiersophos-5
EINECS	Contact for details

Quality Control

Our 4,4'-Bis(T-Butyl)-1,1',2,2'-Tetrakis(Diphenylphosphino)Ferrocene is manufactured under strict quality management protocols. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and elemental analysis, to ensure identity, purity, and consistency meet the specified 98% minimum assay. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at a controlled room temperature (15-25°C) in a cool, dry, and well-ventilated area. Due to its sensitivity to oxidation and light, prolonged exposure to air or ambient light should be avoided to maintain product integrity.

Specification

Item	Specification
Appearance	Orange to red powder or crystals
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Specific Rotation	Contact for details
Heavy Metals	< 20 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.