Description

Fulvestrant 3-Sulfate Sodium Salt is a key sulfated metabolite of the selective estrogen receptor degrader (SERD) fulvestrant. This compound is of significant value in pharmaceutical research and development, particularly for studying drug metabolism, pharmacokinetics, and the biological activity of fulvestrant derivatives. It is primarily required by pharmaceutical companies, contract research organizations (CROs), and academic institutions engaged in advanced oncology research, metabolite identification, and the development of analytical reference standards.

Application

• Pharmaceutical Reference Standard: Serves as a certified reference material (CRM) for quantitative and qualitative analysis in drug development and quality control laboratories.
• Metabolite Research: Critical for in vitro and in vivo studies aimed at identifying, characterizing, and understanding the activity of fulvestrant's major metabolites.
• Bioanalytical Method Development: Used as a standard for developing and validating sensitive HPLC-MS/MS or LC-UV methods for pharmacokinetic (PK) and toxicokinetic (TK) studies.
• DMPK (Drug Metabolism and Pharmacokinetics): Employed in absorption, distribution, metabolism, and excretion (ADME) studies to elucidate the metabolic pathways of fulvestrant.
• Impurity Profiling: Acts as a specified impurity or degradation product standard to ensure the purity and safety of fulvestrant active pharmaceutical ingredient (API) and finished drug products.
• Biological Activity Screening: Utilized in biochemical assays to investigate the potential estrogen receptor binding affinity and antagonistic activity of the sulfated metabolite.

Basic Information

Product Name	Fulvestrant 3-Sulfate Sodium Salt
CAS No.	403656-83-7
Molecular Formula	C32H46F5NaO6S
Molecular Weight	700.76 g/mol
Synonyms	Fulvestrant 3-Sulfate Sodium; ICI 182,780 Sulfate Sodium Salt; 7α-[9-(4,4,5,5,5-Pentafluoropentylsulfinyl)nonyl]estra-1,3,5(10)-triene-3,17β-diol 3-Sulfate Sodium Salt; Faslodex Sulfate Metabolite Sodium Salt; Fulvestrant Sulfate Sodium; (7α,17β)-7-{9-[(4,4,5,5,5-Pentafluoropentyl)sulfinyl]nonyl}estra-1,3,5(10)-triene-3,17-diol 3-(Hydrogen Sulfate) Sodium Salt
EINECS	Contact for details

Quality Control

Our Fulvestrant 3-Sulfate Sodium Salt is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis, to ensure it meets the high standards required for pharmaceutical research. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your regulatory and research needs.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature, typically between 15-25°C (59-77°F). The container should be kept in a dry environment to minimize moisture exposure.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Mass spectrum conforms to structure
Purity (HPLC)	≥95.0%
Water Content (KF)	≤5.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.