Description

Celivarone is a class III antiarrhythmic agent, specifically a benzofuran derivative, developed for the treatment of cardiac arrhythmias. Its primary value lies in its selective inhibition of potassium channels, which helps stabilize the heart's electrical activity and prevent irregular heartbeats. This compound is of significant interest to pharmaceutical research and development teams, contract manufacturing organizations (CMOs), and fine chemical suppliers serving the global cardiovascular drug market. The material is available for use in preclinical studies, formulation development, and as a reference standard.

Application

• Pharmaceutical Active Ingredient (API): Primary use as the active pharmaceutical ingredient in the development of antiarrhythmic medications.
• Reference Standard: Serves as a high-purity analytical standard for quality control and regulatory testing in pharmaceutical laboratories.
• Biochemical Research: Used in cardiovascular research to study ion channel function, cardiac electrophysiology, and mechanisms of arrhythmia.
• Formulation Development: A key intermediate for developing various dosage forms, such as tablets or injectables, in drug product manufacturing.
• Contract Synthesis: Supplied to CROs and CMOs for custom synthesis and scale-up projects under cGMP conditions.

Basic Information

Product Name	Celivarone
CAS No.	401925-43-7
Molecular Formula	C31H38N2O5S
Molecular Weight	550.71 g/mol
Synonyms	SSR149744C; Celivarone hydrochloride; N-[3-[[3-(Diethylamino)propyl]thio]-4-methoxybenzoyl]methanesulfonamilide; (2-Butyl-3-(4-(3-(diethylamino)propylthio)benzoyl)benzofuran-5-yl) methanesulfonate; SSR-149744
EINECS	Contact for details

Quality Control

Our Celivarone is manufactured and tested to meet stringent quality standards suitable for pharmaceutical research and development. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant ICH guidelines and can supply material with specifications aligned with cGMP requirements for advanced clinical trial stages. Certificates of Analysis are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/IR)	Conforms to reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0% Any single unknown impurity ≤0.5%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.