Description

Fmoc-n-Pbf-L-Homoarginine CAS NO 401915-53-5 is a protected amino acid derivative specifically engineered for solid-phase peptide synthesis (SPPS). This compound is critical for researchers and manufacturers requiring high-purity building blocks to construct complex peptides with precision. It is primarily utilized in pharmaceutical R&D, biotechnology, and academic laboratories for the synthesis of therapeutic peptides and biochemical probes.

Application

• Solid-Phase Peptide Synthesis (SPPS): As a key Fmoc-protected building block for the sequential assembly of peptides.
• Pharmaceutical Research: For the development and production of novel peptide-based therapeutics targeting various diseases.
• Bioconjugation: Used in the preparation of peptide-protein conjugates or peptide-labeled compounds for diagnostic and research applications.
• Chemical Biology Studies: Incorporation of the homoarginine moiety into peptides to study protein-protein interactions, enzyme substrates, or inhibitors.
• Process Development: Serves as a critical raw material in the scale-up and GMP manufacturing of peptide active pharmaceutical ingredients (APIs).
• Library Synthesis: For creating combinatorial peptide libraries used in high-throughput screening for drug discovery.

Basic Information

Product Name	Fmoc-n-Pbf-L-Homoarginine
CAS No.	401915-53-5
Molecular Formula	C33H45N5O8S
Molecular Weight	671.81 g/mol
Synonyms	Fmoc-HomoArg(Pbf)-OH; N-α-Fmoc-N-ω-(2,2,4,6,7-pentamethyldihydrobenzofuran-5-sulfonyl)-L-homoarginine; Fmoc-L-Homoarginine(Pbf)-OH; Fmoc-N-ω-Pbf-L-homoarginine; (S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-5-((((2,2,4,6,7-pentamethyldihydrobenzofuran-5-yl)sulfonyl)amino)pentanoic acid; Fmoc-Har(Pbf)-OH; Fmoc-NG-Pbf-L-homoarginine
EINECS	Contact for details

Quality Control

Our Fmoc-n-Pbf-L-Homoarginine is produced under stringent quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis, and identity confirmation, to ensure it meets the high standards required for sensitive peptide synthesis applications. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability and purity. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Specific Rotation	Contact for details
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residual Solvents	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.