Description

1,1,1-Trifluoro-3-(Phenethylamino)-2-Propanol CAS NO 400878-20-8 is a specialized fluorinated amino alcohol building block of significant interest in advanced organic synthesis. Its molecular structure, featuring both a phenethylamino group and a trifluoromethylated alcohol moiety, makes it a valuable precursor for constructing complex molecules with tailored properties. This compound is primarily utilized by research and development chemists in the pharmaceutical and agrochemical industries for the development of new active ingredients, where the introduction of fluorine atoms can dramatically alter a molecule's bioavailability, metabolic stability, and binding affinity.

Application

• Pharmaceutical Intermediate: A key synthon for the research and development of novel drug candidates, particularly in central nervous system (CNS) and metabolic disease research.
• Agrochemical Synthesis: Used in the creation of advanced pesticides and herbicides, where the fluorine atoms enhance lipophilicity and environmental stability.
• Ligand and Catalyst Development: Serves as a chiral building block or precursor for ligands used in asymmetric catalysis.
• Material Science Research: Employed in the synthesis of fluorinated polymers or specialty chemicals with unique surface properties.
• Chemical Biology Probes: Useful for synthesizing molecular probes to study biological processes and enzyme interactions.
• Custom Synthesis and Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for client-specific synthesis projects.

Basic Information

Product Name	1,1,1-Trifluoro-3-(Phenethylamino)-2-Propanol
CAS No.	400878-20-8
Molecular Formula	C₁₁H₁₄F₃NO
Molecular Weight	233.23 g/mol
Synonyms	3-(2-Phenylethylamino)-1,1,1-trifluoro-2-propanol; 1,1,1-Trifluoro-3-[(2-phenylethyl)amino]-2-propanol; 2-Propanol, 1,1,1-trifluoro-3-[(2-phenylethyl)amino]-; N-Phenethyl-1,1,1-trifluoro-3-amino-2-propanol; 3-(Phenethylamino)-1,1,1-trifluoropropan-2-ol; TFAP; Phenethylamino-trifluoropropanol
EINECS	Contact for details

Quality Control

Our 1,1,1-Trifluoro-3-(Phenethylamino)-2-Propanol is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity assessment and NMR for structural confirmation, to ensure it meets the high standards required for research and development applications. Certificates of Analysis (COA) detailing batch-specific results are available upon request to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its chemical nature, it should be kept separate from strong acids and bases. Keep the container tightly sealed when not in use to minimize exposure to atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.