Description

7 β - Amino - 3 - [4 - Pyridyl - 2 - Thiazole Sulfur Radical ] - 3 - Cephem - 4 - Carboxylic Acid ·2Hcl is a high-purity, advanced pharmaceutical intermediate belonging to the cephalosporin class of β-lactam antibiotics. This compound is critical for the research and development of next-generation antibacterial agents, offering a sophisticated chemical scaffold for structural modification. It is primarily utilized by pharmaceutical R&D laboratories, fine chemical manufacturers, and academic institutions engaged in antimicrobial drug discovery and synthesis.

Application

• Key Intermediate in Antibiotic Synthesis: Serves as a crucial building block in the multi-step synthesis of novel cephalosporin-based antibiotics.
• Pharmaceutical Research & Development: Used in medicinal chemistry programs for structure-activity relationship (SAR) studies to develop new antibacterial agents with improved efficacy and spectrum.
• Fine Chemical Manufacturing: Employed in the production of high-value active pharmaceutical ingredients (APIs) for preclinical and clinical trial materials.
• Academic & Institutional Research: A valuable reagent for studying β-lactam chemistry, antibiotic resistance mechanisms, and novel drug delivery systems.
• Process Chemistry Development: Used to optimize and scale up synthetic routes for new antibiotic candidates in pilot plants.

Basic Information

Product Name	7 β - Amino - 3 - [4 - Pyridyl - 2 - Thiazole Sulfur Radical ] - 3 - Cephem - 4 - Carboxylic Acid ·2Hcl
CAS No.	400827-64-7
Molecular Formula	C15H13N5O4S2 · 2HCl
Molecular Weight	488.34 g/mol (Free base) / 561.28 g/mol (as 2HCl salt)
Synonyms	7β-Amino-3-[(4-pyridyl-2-thiazolyl)thio]-3-cephem-4-carboxylic acid dihydrochloride; 7β-Amino-3-(4-pyridin-2-yl-1,3-thiazol-2-ylsulfanyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid hydrochloride (1:2); 7-ACA Pyridyl Thiazole Derivative; Cephalosporin C-7 Amino Intermediate; (6R,7R)-7-Amino-3-[(4-pyridin-2-yl-1,3-thiazol-2-yl)sulfanyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid dihydrochloride
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems, ensuring batch-to-batch consistency for critical R&D and scale-up work. The material undergoes comprehensive analytical testing, including HPLC for purity and chiral integrity, NMR for structural confirmation, and stringent control of residual solvents and impurities. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting all specifications. We support development under cGMP guidelines for pharmaceutical applications upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption and potential degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.