Description

Carbamic Acid, [(1S)-1-(Aminomethyl)-2-Methylpropyl]-, 1,1-Dimethylethyl Ester is a chiral, protected amino acid derivative of significant value in advanced organic synthesis. This compound serves as a crucial high-purity building block for the construction of complex peptide mimetics and active pharmaceutical ingredients (APIs). It is primarily utilized by pharmaceutical R&D teams and fine chemical manufacturers engaged in the development of novel therapeutic agents.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of protease inhibitors and other peptide-based drugs.
• Peptidomimetic Research: Used to introduce the (S)-2-amino-3-methylbutyl moiety into non-natural peptide backbones for structure-activity relationship (SAR) studies.
• API Development: Serves as a protected amino acid component in the multi-step synthesis of complex target molecules in preclinical and process chemistry.
• Asymmetric Synthesis: Employed as a chiral auxiliary or building block in stereoselective reactions to create enantiomerically pure compounds.
• Bioconjugation Chemistry: Potential use in linker technology for antibody-drug conjugates (ADCs) or other targeted delivery systems.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs for the production of client-specific advanced intermediates under cGMP conditions.

Basic Information

Item	Detail
Product Name	Carbamic Acid, [(1S)-1-(Aminomethyl)-2-Methylpropyl]-, 1,1-Dimethylethyl Ester
CAS No.	400652-49-5
Molecular Formula	C10H21NO2
Molecular Weight	187.28 g/mol
Synonyms	(S)-tert-Butyl (1-amino-3-methylbutan-2-yl)carbamate; (S)-2-((tert-Butoxycarbonyl)amino)-3-methylbutylamine; (S)-N-Boc-1,2-diamino-3-methylbutane; Boc-L-2,3-diaminobutanoic acid amine derivative; (1S)-1-(Aminomethyl)-2-methylpropyl carbamic acid tert-butyl ester; (S)-tert-Butyl (2-amino-1-(aminomethyl)propyl)carbamate; L-2,3-Diaminobutyric acid derivative
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality protocols to ensure batch-to-batch consistency for critical R&D and scale-up processes. Quality is verified through comprehensive analytical methods including HPLC, chiral GC, and NMR to confirm identity, purity, and enantiomeric excess. A Certificate of Analysis (COA) detailing all specifications is provided with each shipment. We support development under cGMP guidelines for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under a dry inert atmosphere (e.g., nitrogen or argon) to prevent degradation. Keep the container tightly sealed when not in use.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral GC/HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.