Description

2-(Trifluoromethyl)Phenyl Acetate is a specialized fluorinated aromatic ester, a key building block in advanced organic synthesis. This compound is valued for its ability to introduce the trifluoromethylphenyl moiety, a group known to significantly alter the physicochemical properties of target molecules, enhancing metabolic stability and lipophilicity. It is primarily sought after by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A crucial precursor in the synthesis of drug candidates, particularly those targeting central nervous system (CNS) disorders, where the trifluoromethyl group can improve blood-brain barrier penetration.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides, where the fluorine atoms contribute to increased biological activity and environmental persistence.
• Liquid Crystal & OLED Materials: Serves as a building block for fluorinated components in electronic display materials, contributing to improved dielectric anisotropy and thermal stability.
• Polymer Modification: Employed to introduce fluorine-containing side chains into polymers, enhancing their chemical resistance, thermal stability, and surface properties.
• Organic Synthesis Reagent: Utilized in cross-coupling reactions, esterifications, and as a protecting group in complex multi-step synthetic routes.
• Chemical Research & Development: A valuable tool for medicinal chemistry and material science research in academic and industrial R&D laboratories.

Basic Information

Product Name	2-(Trifluoromethyl)Phenyl Acetate
CAS No.	400629-06-3
Molecular Formula	C9H7F3O2
Molecular Weight	204.15 g/mol
Synonyms	2-(Trifluoromethyl)phenyl acetate; α,α,α-Trifluoro-o-cresyl acetate; 1-Acetoxy-2-(trifluoromethyl)benzene; o-(Trifluoromethyl)phenyl acetate; 2-(Trifluoromethyl)phenol acetate; Acetic acid 2-(trifluoromethyl)phenyl ester; (2-Trifluoromethylphenyl) acetate
EINECS	Contact for details

Quality Control

Our 2-(Trifluoromethyl)Phenyl Acetate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and IR spectroscopy, to ensure identity, purity, and consistency. We provide full traceability and detailed Certificates of Analysis (COA) with every shipment, confirming compliance with agreed specifications. Our quality commitment supports applications in cGMP and ISO-regulated environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from strong bases and incompatible materials such as strong oxidizing agents. The container should be kept tightly sealed to prevent moisture absorption and potential decomposition.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Individual impurity ≤ 0.5%, Total impurities ≤ 2.0%
Refractive Index	1.450 - 1.460
Density	1.28 - 1.32 g/cm³

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.