Description

1-Trimethylsilylethynyl-3,5-Dimethoxybenzene is a specialized organosilicon building block featuring a trimethylsilyl-protected alkyne group on a dimethoxybenzene core. This compound is valued for its role as a key synthetic intermediate in advanced organic and medicinal chemistry, enabling precise molecular construction. It is primarily utilized by research chemists and process development scientists in the pharmaceutical, agrochemical, and materials science industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: Serves as a critical building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for compounds requiring alkyne functionalization under protective conditions.
• Agrochemical Synthesis: Used in the research and development of novel crop protection agents and herbicides, where its structural motifs can be incorporated into bioactive molecules.
• Material Science Research: Acts as a precursor for advanced organic materials, including polymers and liquid crystals, where the silyl-protected alkyne allows for controlled polymerization or cross-linking reactions.
• Chemical Biology Probes: Employed in the synthesis of molecular probes and tags for bio-conjugation and labeling applications via click chemistry methodologies.
• Academic & Industrial R&D: A versatile reagent for methodology development and exploratory synthesis in organic chemistry laboratories.

Basic Information

Product Name	1-Trimethylsilylethynyl-3,5-Dimethoxybenzene
CAS No.	400608-30-2
Molecular Formula	C₁₄H₂₀O₂Si
Molecular Weight	248.40 g/mol
Synonyms	3,5-Dimethoxy-1-[(trimethylsilyl)ethynyl]benzene; 1-Ethynyl-3,5-dimethoxybenzene trimethylsilyl ether; (3,5-Dimethoxyphenyl)ethynyltrimethylsilane; TMS-Ethynyl-3,5-dimethoxybenzene; Trimethyl((3,5-dimethoxyphenyl)ethynyl)silane
EINECS	Contact for details

Quality Control

Our 1-Trimethylsilylethynyl-3,5-Dimethoxybenzene is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and FTIR, to ensure high purity and consistent performance. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.