Description

(R)-α-[[[(Phenylmethoxy)Carbonyl]Amino]Oxy]-Benzenepropanoic Acid is a chiral, non-natural amino acid derivative of significant interest in advanced organic synthesis. This compound serves as a versatile building block for constructing complex molecules, particularly due to its protected aminooxy and carboxylic acid functional groups. It is primarily utilized by pharmaceutical research and fine chemical synthesis teams for developing novel active ingredients and sophisticated chemical probes.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new drug candidates, especially for targeted therapies.
• Peptidomimetic Synthesis: Used to incorporate non-standard amino acid structures into peptide chains to enhance stability, bioavailability, or biological activity.
• Bioconjugation & Linker Chemistry: The aminooxy group enables selective oxime ligation with aldehydes and ketones, useful for labeling proteins, antibodies, or other biomolecules.
• Chemical Biology Probes: Serves as a component in the design of activity-based probes and other tools for studying biological pathways and enzyme function.
• Asymmetric Synthesis: Employed as a chiral auxiliary or reagent in stereoselective reactions to induce enantiomeric purity in final products.
• Academic & Industrial R&D: A valuable reagent for methodological development in organic chemistry and medicinal chemistry laboratories worldwide.

Basic Information

Product Name	(R)-α-[[[(Phenylmethoxy)Carbonyl]Amino]Oxy]-Benzenepropanoic Acid
CAS No.	49857-06-9
Molecular Formula	C17H17NO5
Molecular Weight	315.32 g/mol
Synonyms	(R)-2-[[(Benzyloxycarbonyl)amino]oxy]-3-phenylpropanoic acid; (R)-N-Cbz-Aminoxy-phenylalanine; (R)-Cbz-Aoa-Phe-OH; (R)-α-[[[(Benzyloxy)carbonyl]amino]oxy]benzenepropanoic acid; (R)-O-(N-Cbz-amino)-L-phenylalanine; Z-Aoa-(R)-Phe-OH; (R)-N-[(Benzyloxy)carbonyl]aminooxy-phenylalanine; (R)-2-((((Benzyloxy)carbonyl)amino)oxy)-3-phenylpropanoic acid
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. We provide material with typical purities suitable for research and development applications. Certificates of Analysis (COA) detailing identity, purity (by HPLC), and specific impurity profiles are available upon request. Our quality system supports the needs of cGMP-compliant development work.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Keep the container sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Optical Rotation	Specific range available on COA
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.