Description

2,2-Difluoropropionitrile is a versatile fluorinated nitrile building block essential for advanced organic synthesis. Its unique structure, featuring two fluorine atoms on the same carbon, makes it a critical intermediate for introducing difluoroalkyl motifs into target molecules. This compound is particularly valuable for researchers and manufacturers in the pharmaceutical and agrochemical sectors seeking to enhance the metabolic stability and bioavailability of new chemical entities. Its high volatility also makes it suitable for specialized applications in materials science and electronics.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel active pharmaceutical ingredients (APIs), especially those requiring difluoromethyl or difluoroalkyl groups to modulate potency and pharmacokinetics.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides where fluorine substitution improves efficacy and environmental profile.
• Liquid Crystal & Electronic Chemicals: Serves as a precursor for fluorinated compounds used in liquid crystal displays (LCDs) and dielectric materials.
• Organic Synthesis Reagent: Employed in nucleophilic addition and cyclization reactions to construct complex heterocycles and fine chemicals.
• Material Science Research: Utilized in the development of novel fluorinated polymers and specialty materials with unique surface properties.
• Chemical Reference Standard: Supplied as a high-purity standard for analytical method development and quality control in fluorochemical production.

Basic Information

Product Name	2,2-Difluoropropionitrile
CAS No.	49781-49-9
Molecular Formula	C3H3F2N
Molecular Weight	91.06 g/mol
Synonyms	2,2-Difluoropropanenitrile; Propanenitrile, 2,2-difluoro-; α,α-Difluoropropionitrile; Difluoropropionitrile; 2,2-Difluoropropiononitrile; DFPN
EINECS	Contact for details

Quality Control

Our 2,2-Difluoropropionitrile is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including chromatography and spectroscopy, to confirm identity and purity. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting key parameters such as assay and impurity profiles. We adhere to cGMP principles where applicable to support our customers in regulated industries.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, well-ventilated area, away from heat sources and incompatible materials such as strong bases and reducing agents. Due to its highly volatile nature, ensure containers are kept tightly sealed when not in use to prevent evaporation and concentration changes. Recommended storage temperature is 2-8°C for long-term stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (GC)	Individual impurity ≤ 1.0%
Total Impurities	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.