Description

n-Desmethyl Prochlorperazine Dimaleate is a key pharmaceutical intermediate and metabolite of the antipsychotic agent prochlorperazine. This compound is of significant importance for research and development in neuropharmacology and for the synthesis of related therapeutic agents. It is primarily required by pharmaceutical manufacturers, analytical laboratories, and research institutions engaged in drug metabolism studies, impurity profiling, and the development of new central nervous system (CNS) active compounds.

Application

• Pharmaceutical Intermediate: Critical for the synthesis and research of prochlorperazine and its derivatives.
• Reference Standard: Used as a certified reference material (CRM) in analytical laboratories for method development and validation.
• Metabolite Studies: Essential for in-vitro and in-vivo drug metabolism and pharmacokinetic (DMPK) research.
• Impurity Profiling: Serves as a known impurity standard in the quality control of prochlorperazine active pharmaceutical ingredients (APIs) and finished dosage forms.
• Biochemical Research: Utilized in studies investigating dopamine receptor interactions and the mechanisms of phenothiazine-class drugs.

Basic Information

Product Name	n-Desmethyl Prochlorperazine Dimaleate
CAS No.	49780-18-9
Molecular Formula	C24H28ClN3O8S
Molecular Weight	554.02 g/mol
Synonyms	Prochlorperazine Impurity F; 2-Chloro-10-[3-(4-methylpiperazin-1-yl)propyl]phenothiazine Dimaleate; Desmethylprochlorperazine Dimaleate; 1-[3-(2-Chloro-10H-phenothiazin-10-yl)propyl]-4-methylpiperazine Dimaleate; N-Desmethyl Prochlorperazine Maleate Salt; Prochlorperazine Metabolite Dimaleate; Compazine Related Compound F
EINECS	Contact for details

Quality Control

Our n-Desmethyl Prochlorperazine Dimaleate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including identification by spectroscopic methods (IR, NMR), purity determination by HPLC, and control of related substances and residual solvents. Certificates of Analysis (COA) detailing all test results are provided and can be tailored to meet specific pharmacopeial or internal quality standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.