Description

Lhrh, Phe(7)- CAS NO 49761-68-4 is a synthetic peptide analog of Luteinizing Hormone-Releasing Hormone (LHRH), specifically modified with a phenylalanine substitution at position 7. This modification is critical for enhancing its stability and receptor-binding affinity, making it a valuable research biochemical and a key intermediate in pharmaceutical development. It is primarily utilized by research institutions and pharmaceutical companies engaged in endocrinology, oncology, and reproductive medicine. The compound serves as a fundamental tool for studying hormone-receptor interactions and developing targeted therapeutic agents.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of advanced LHRH agonist and antagonist drug candidates for treating hormone-dependent conditions.
• Biomedical Research: Used as a reference standard and active probe in in vitro and in vivo studies to investigate the pituitary-gonadal axis and hormone signaling pathways.
• Peptide Chemistry Development: Serves as a model compound for optimizing solid-phase peptide synthesis (SPPS) and purification techniques for modified peptides.
• Diagnostic Reagent Production: Employed in the development and calibration of immunoassays and diagnostic kits for measuring LHRH and related hormones.
• Academic & Preclinical Studies: Fundamental for university and institutional research exploring novel therapeutic approaches for cancers like prostate and breast cancer, as well as reproductive disorders.

Basic Information

Product Name	Lhrh, Phe(7)- CAS NO 49761-68-4
CAS No.	49761-68-4
Molecular Formula	C59H78N16O13
Molecular Weight	1211.4 g/mol
Synonyms	Phe(7)-LHRH; [Phe7]-LHRH; Luteinizing Hormone-Releasing Hormone (7-Phenylalanine); LHRH (7-Phe); GnRH I (7-Phe); Gonadorelin (7-Phe) analog; Luliberin (7-Phe) analog; Pyro-Glu-His-Trp-Ser-Tyr-Phe-Leu-Arg-Pro-Gly-NH2 (Phe7)
EINECS	Contact for details

Quality Control

Our Lhrh, Phe(7)- is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation, to ensure it meets rigorous research and development standards. Certificates of Analysis (COA) detailing purity, peptide content, and related substances are provided with every shipment. We support compliance with relevant pharmacopeial guidelines for peptide intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as specified on the label or COA. This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation from atmospheric moisture. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to theoretical mass
Purity (HPLC)	≥ 95.0%
Peptide Content	≥ 80.0%
Single Impurity (HPLC)	≤ 2.0%
Water Content (KF)	≤ 8.0%
Acetate Content (HPLC)	≤ 15.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.