Description

tert-Butyl [(1S)-1-(Hydrazinocarbonyl)-3-(Methylthio)Propyl]Carbamate is a high-purity, chiral building block of significant interest in advanced organic synthesis. Its value lies in the unique combination of a protected amine, a hydrazide moiety, and a thioether functional group within a single, stereodefined molecule. This compound is primarily required by research and development chemists in the pharmaceutical and agrochemical industries for the construction of complex molecules, particularly in peptidomimetic and heterocyclic chemistry.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of novel active pharmaceutical ingredients (APIs), especially those targeting protease inhibition or requiring specific stereochemistry.
• Peptidomimetic Research: Used in the design and synthesis of peptide analogs and mimetics to improve metabolic stability and bioavailability of therapeutic candidates.
• Heterocycle Formation: Serves as a precursor for the construction of various nitrogen- and sulfur-containing heterocycles, such as pyrazoles and thiazolidines, which are common scaffolds in medicinal chemistry.
• Agrochemical Synthesis: Employed in the development of new herbicides, fungicides, or insecticides that utilize chiral, sulfur-based chemistry.
• Chemical Biology Probes: Useful for creating labeled or tagged molecular probes to study enzyme mechanisms or protein-protein interactions.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the life sciences sector.

Basic Information

Product Name	tert-Butyl [(1S)-1-(Hydrazinocarbonyl)-3-(Methylthio)Propyl]Carbamate
CAS No.	49759-74-2
Molecular Formula	C10H21N3O3S
Molecular Weight	263.36 g/mol
Synonyms	(S)-2-((tert-Butoxycarbonyl)amino)-4-(methylthio)butanehydrazide; Boc-L-Methionine hydrazide; N-Boc-L-Methionine hydrazide; tert-Butyl (S)-(1-(hydrazinecarbonyl)-3-(methylthio)propyl)carbamate; (1S)-1-[[(1,1-Dimethylethoxy)carbonyl]amino]-3-(methylthio)propyl]carboxylic acid hydrazide; Boc-Met-NHNH2; Nα-Boc-L-Methionyl hydrazide
EINECS	Contact for details

Quality Control

Our tert-Butyl [(1S)-1-(Hydrazinocarbonyl)-3-(Methylthio)Propyl]Carbamate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification, to ensure it meets the high standards required for research and cGMP (current Good Manufacturing Practice) starting material applications. Certificates of Analysis (COA) detailing identity, purity (HPLC), chiral purity, and related substances are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C for long-term stability. This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent decomposition. Allow the sealed container to equilibrate to room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Related Substances (HPLC)	Any single impurity ≤ 0.5%, Total impurities ≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.