Description

2-[n-[3-(Acetylamino)-2,4,6-Triiodo-5-(Methylaminocarbonyl)Benzoyl]-n-Methylamino]Acetic Acid is a high-purity, iodinated organic compound primarily used as a key intermediate in the synthesis of advanced X-ray contrast media. Its complex molecular structure, featuring a triiodinated benzene core, is critical for imparting the necessary radiopacity required in diagnostic imaging agents. This compound is essential for pharmaceutical manufacturers and fine chemical suppliers developing non-ionic, low-osmolar contrast agents for enhanced patient safety and diagnostic clarity in medical procedures such as angiography, urography, and computed tomography (CT) scans.

Application

• Pharmaceutical Intermediate: Primary building block for synthesizing non-ionic X-ray contrast media like iopamidol, iohexol, and other modern contrast agents.
• Diagnostic Imaging Agent Synthesis: Critical precursor in the production of iodinated compounds used in CT scans, angiography, and myelography.
• Research & Development: Used in academic and industrial R&D for developing new generations of radiopaque materials with improved safety profiles.
• Fine Chemical Production: Serves as a specialized intermediate for custom synthesis and contract manufacturing in the pharmaceutical sector.
• Contrast Media Formulation: Integral to formulating final drug products that require high purity and strict control over isomer content and impurity levels.

Basic Information

Product Name	2-[n-[3-(Acetylamino)-2,4,6-Triiodo-5-(Methylaminocarbonyl)Benzoyl]-n-Methylamino]Acetic Acid
CAS No.	49755-86-4
Molecular Formula	C14H14I3N3O5
Molecular Weight	704.99 g/mol
Synonyms	5-Acetamido-2,4,6-triiodo-N-methyl-N-(carboxymethyl)isophthalamic Acid; Iopamidol Intermediate; Iopamidol Related Compound; 5-Acetamido-2,4,6-triiodo-N-methylisophthalamic Acid N-(Carboxymethyl) Amide; AD-101; AD 101; AD101; NSC 339224
EINECS	Contact for details

Quality Control

Our production of this critical pharmaceutical intermediate adheres to strict cGMP guidelines to ensure batch-to-batch consistency and traceability. Quality is verified through a comprehensive battery of tests including HPLC for purity and impurity profiling, residual solvent analysis, and specific identification tests. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting compliance with agreed specifications for assay, related substances, heavy metals, and other critical parameters. We support audits and can provide DMF (Drug Master File) references where applicable.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); containers must be kept tightly sealed to prevent absorption of atmospheric moisture, which can affect stability and purity. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single unknown impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Heavy Metals	≤ 20 ppm
Loss on Drying	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.