Description

(6R-Trans)-7-Amino-3-[[(2-Methyl-2H-Tetrazol-5-Yl)Thio]Methyl]-8-Oxo-5-Thia-1-Azabicyclo[4.2.0]Oct-2-Ene-2-Carboxylic Acid is a high-purity advanced pharmaceutical intermediate, specifically a cephalosporin nucleus derivative. This compound is critical for the synthesis of third-generation cephalosporin antibiotics, offering a key structural component for developing potent antimicrobial agents. It is primarily required by pharmaceutical R&D laboratories, API manufacturers, and fine chemical producers focused on antibiotic development and production.

Application

• Active Pharmaceutical Ingredient (API) Synthesis: Core intermediate for manufacturing third-generation cephalosporin antibiotics such as cefotetan and related compounds.
• Pharmaceutical Research & Development: Serves as a crucial building block in medicinal chemistry for designing and testing new β-lactam antibiotic candidates.
• Process Chemistry & Scale-Up: Used in optimizing synthetic routes and scaling production processes for cephalosporin-based drugs.
• Reference Standard: Employed as a high-purity analytical standard for quality control and regulatory testing of finished pharmaceutical products.
• Fine Chemical Manufacturing: A key intermediate for specialized chemical suppliers serving the global pharmaceutical supply chain.

Basic Information

Item	Details
Product Name	(6R-Trans)-7-Amino-3-[[(2-Methyl-2H-Tetrazol-5-Yl)Thio]Methyl]-8-Oxo-5-Thia-1-Azabicyclo[4.2.0]Oct-2-Ene-2-Carboxylic Acid
CAS No.	49753-68-6
Molecular Formula	C11H13N7O3S2
Molecular Weight	355.40 g/mol
Synonyms	7-ACA Tetrazole Derivative; 7-Aminocephalosporanic Acid Tetrazolylthio Methyl Derivative; Cefotetan Intermediate; 7β-Amino-3-[(1-methyl-1H-tetrazol-5-ylthio)methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic Acid; (6R,7R)-7-Amino-3-[[(2-methyl-2H-tetrazol-5-yl)thio]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic Acid; 7-ACT; 7-Amino-3-(1-methyl-1H-tetrazole-5-ylthiomethyl)-3-cephem-4-carboxylic Acid
EINECS	Contact for details

Quality Control

Our (6R-Trans)-7-Amino-3-[[(2-Methyl-2H-Tetrazol-5-Yl)Thio]Methyl]-8-Oxo-5-Thia-1-Azabicyclo[4.2.0]Oct-2-Ene-2-Carboxylic Acid is manufactured under strict quality management systems to ensure it meets the exacting standards required for pharmaceutical synthesis. Production adheres to current Good Manufacturing Practices (cGMP) where applicable. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation. A detailed Certificate of Analysis (COA) is provided with every shipment to guarantee traceability and compliance with your specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed and under an inert atmosphere (e.g., nitrogen) for long-term storage to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.