Description

Diethyl 2-(Trifluoromethoxy)Phenylamino-n-Methylenemalonate is a specialized fluorinated malonate derivative that serves as a critical advanced intermediate in organic synthesis. Its molecular architecture, featuring a trifluoromethoxy phenylamino group, makes it a valuable building block for constructing complex molecules with enhanced biological activity and physicochemical properties. This compound is primarily utilized by research institutions and industrial R&D departments in the pharmaceutical and agrochemical sectors for the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders and inflammatory diseases.
• Agrochemical Synthesis: Building block for developing next-generation herbicides and insecticides with improved efficacy and environmental profiles.
• Material Science Research: Used in the creation of specialty polymers and liquid crystals where the trifluoromethoxy group imparts unique thermal and chemical resistance.
• Chemical Biology Probes: Serves as a scaffold for creating fluorescent tags and molecular probes due to its modifiable functional groups.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for scale-up and process development of client-specific molecules.

Basic Information

Product Name	Diethyl 2-(Trifluoromethoxy)Phenylamino-n-Methylenemalonate
CAS No.	49713-41-9
Molecular Formula	C₁₅H₁₆F₃NO₅
Molecular Weight	347.29 g/mol
Synonyms	Diethyl (2-(trifluoromethoxy)phenylamino)methylene malonate; Diethyl [[[2-(Trifluoromethoxy)phenyl]amino]methylene]propanedioate; 2-(Trifluoromethoxy)phenylamino-methylenemalonic Acid Diethyl Ester; Propanedioic acid, [[[2-(trifluoromethoxy)phenyl]amino]methylene]-, diethyl ester; Ethyl 2-((2-(trifluoromethoxy)phenyl)amino)methylene)malonate
EINECS	Contact for details

Quality Control

Our production of Diethyl 2-(Trifluoromethoxy)Phenylamino-n-Methylenemalonate adheres to stringent quality management protocols. Each batch is characterized and verified using advanced analytical techniques including HPLC, GC, NMR, and mass spectrometry to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all critical specifications are provided with every shipment, ensuring full traceability and compliance with customer and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.