Description

L-Methionine-Methyl-13C CAS NO 49705-26-2 is a stable isotope-labeled analog of the essential amino acid L-Methionine, where the methyl group is enriched with the Carbon-13 isotope. This compound is a critical tool for advanced research and analytical applications, enabling precise metabolic pathway tracing and quantitative analysis. It is primarily utilized by scientists and manufacturers in the pharmaceutical, nutritional science, and biotechnology sectors for applications such as mass spectrometry-based proteomics, metabolic flux analysis, and the development of labeled internal standards.

Application

• Metabolic Research & Flux Analysis: Used as a tracer to study methionine metabolism, methylation cycles, and sulfur amino acid pathways in cell cultures, tissues, and whole organisms.
• Quantitative Proteomics & Biomarker Discovery: Serves as a precursor for the synthesis of stable isotope-labeled peptides and proteins, enabling accurate mass spectrometry-based quantification.
• Pharmaceutical Development: Employed in the research and development of novel drugs, particularly in pharmacokinetic (PK) and absorption, distribution, metabolism, and excretion (ADME) studies using mass spectrometry.
• Internal Standard Synthesis: A key starting material for creating isotopically labeled internal standards used to ensure accuracy and precision in bioanalytical methods (LC-MS/MS, GC-MS).
• Nutritional Science Research: Applied in studies investigating protein metabolism, amino acid requirements, and the metabolic fate of dietary methionine.
• Diagnostic Agent Development: Potential use in the formulation of advanced diagnostic probes for medical imaging techniques like magnetic resonance spectroscopy (MRS).

Basic Information

Product Name	L-Methionine-Methyl-13C
CAS No.	49705-26-2
Molecular Formula	C13CH3SCH2CH2CH(NH2)COOH
Molecular Weight	150.21 g/mol (for 13C1 labeled form)
Synonyms	(2S)-2-Amino-4-((13C)methylsulfanyl)butanoic acid; L-Methionine (methyl-13C); L-Methionine-13C-methyl; Methionine (L-13C-methyl); (S)-2-Amino-4-((13C)methylthio)butyric acid; L-2-Amino-4-((13C)methylmercapto)butyric acid; Stable Isotope Labeled L-Methionine
EINECS	Contact for details

Quality Control

Our L-Methionine-Methyl-13C is produced under controlled conditions to ensure the highest isotopic and chemical purity. Each batch undergoes rigorous analytical testing, including HPLC for chemical purity, NMR and MS for isotopic enrichment verification, and chiral analysis to confirm enantiomeric purity. Certificates of Analysis (COA) detailing batch-specific results for assay, isotopic purity, and related substances are provided. We adhere to stringent quality management protocols suitable for research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider storing under an inert atmosphere such as argon or nitrogen to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Isotopic Enrichment	≥ 99 atom % 13C
Chemical Purity (HPLC)	≥ 98.0%
Optical Rotation	[α]D20: +21° to +25° (c=1 in 1N HCl)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.