Description

3-Bromo-5-Nitrobenzonitrile is a versatile and high-purity aromatic nitrile building block, essential for advanced organic synthesis. Its unique structure, featuring both bromo and nitro substituents, makes it a critical intermediate for constructing complex molecules in pharmaceutical and agrochemical research. This compound is primarily sought by R&D chemists and process development scientists working on active pharmaceutical ingredients (APIs), crop protection agents, and functional materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly in the development of kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and pesticides, leveraging its reactive halogen and nitro groups.
• Material Science Research: Serves as a building block for creating specialized polymers, liquid crystals, and organic electronic materials due to its rigid, substituted benzene core.
• Cross-Coupling Reactions: The bromine atom is an excellent site for palladium-catalyzed reactions like Suzuki, Sonogashira, or Buchwald-Hartwig couplings to introduce complex substituents.
• Nitro Group Reduction: The nitro functionality can be selectively reduced to an amine, enabling the synthesis of diamino or amino-bromo benzonitrile derivatives.
• Cyanohydrin Chemistry: The nitrile group can be further functionalized, providing a pathway to amides, acids, and heterocycles.

Basic Information

Product Name	3-Bromo-5-Nitrobenzonitrile
CAS No.	49674-15-9
Molecular Formula	C7H3BrN2O2
Molecular Weight	227.02 g/mol
Synonyms	5-Bromo-3-nitrobenzonitrile; Benzonitrile, 3-bromo-5-nitro-; 3-Bromo-5-nitro-benzonitrile; 3-Bromo-5-nitrobenzenecarbonitrile; 5-Nitro-3-bromobenzonitrile; 3-Bromo-5-nitro-phenyl cyanide; 3-Bromo-5-cyanobenzene
EINECS	Contact for details

Quality Control

Our 3-Bromo-5-Nitrobenzonitrile is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our commitment to quality supports your research and development needs with reliable, high-purity intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from strong oxidizing agents, strong bases, and sources of ignition. The compound is light-sensitive and should be stored away from light.

Specification

Item	Specification
Appearance	Off-white to pale yellow crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	145 - 150 °C
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.